Moffitt Aging and Cancer Program Development

（申请人描述）本规划与发展（P20）拨款申请是根据RFA CA-030504提交的，旨在为nci指定的综合癌症中心H. Lee Moffitt癌症中心和研究所的老龄化与癌症研究项目寻求资金。莫菲特癌症中心非常适合开展这样的项目，因为：1)它位于老年人人口众多的地理区域；2)在中心接受治疗的老年人数量较多；3)该中心多年来的高级成人肿瘤临床项目为开展衰老和癌症研究合作提供了初步机会；4)许多癌症中心成员有兴趣扩大他们的关注范围，包括与衰老相关的问题；5)南佛罗里达大学（所有癌症中心的成员都在这里担任教职）的众多老年研究人员有兴趣扩大他们的研究重点，包括与癌症相关的问题。该奖项提供的资金将用于发展与最近NINNCI研讨会报告中确定的五个老龄化和癌症主题相关的研究：治疗效果和耐受性，共病和癌症的影响，社会心理问题和医疗影响，姑息治疗，临终关怀和疼痛缓解，以及衰老和癌症生物学。为了实现这一目标，资金将用于支持这些领域中有前途的试点研究，以及旨在促进老龄和癌症研究人员之间进一步合作的各种规划和教育活动。基金还将用于聘用基础科学和临床研究领域的新教员，这些教员的背景和专业知识将跨越被确定为有合作前景的领域。此外，资金将用于在健康结果测量中建立一个新的共享资源，该资源可能被许多受资助的研究人员用于进行衰老和癌症研究，并加强现有的共享资源，为开展临床试验提供生物统计学支持和支持。申请文件中包含的承诺书表明了莫菲特癌症中心高层领导对这项工作的大力支持。与RFA的目标一致，该奖项的获得预计将导致衰老和癌症研究项目的发展，该项目将值得纳入莫菲特癌症中心未来的癌症中心支持拨款申请。

DESCRIPTION: (Applicant's Description) This Planning and Development (P20) Grant application, submitted in response to RFA CA-030504, seeks funding to develop an Aging and Cancer Research Program at the H. Lee Moffitt Cancer Center and Research Institute, an NCI-designated Comprehensive Cancer Center. The Moffitt Cancer Center is ideally suited to develop such a program based on: 1) its location in a geographic region with a large population of older adults; 2) the relatively large number of older adults receiving treatment at the center; 3) the existence for many years of a Senior Adult Oncology Clinical Program at the center that has provided initial opportunities to develop aging and cancer research collaborations; 4) the presence of numerous cancer center members interested in expanding their focus to include issues related to aging; and 5) the presence of numerous aging researchers at the University of South Florida (where all cancer center members hold their faculty appointments) interested in expanding their focus to include issues related to cancer. Funds provided by this award would be used to develop research related to five aging and cancer themes identified in a recent NINNCI Workshop Report: Treatment Efficacy and Tolerance, Effects of Comorbidity and Cancer, Psychosocial Issues and Medical Effects, Palliative Care, End-of-Life Care, and Pain Relief, and the Biology of Aging and Cancer. Toward this end, funds would be used to support promising pilot research in each of these areas as well as a variety of planning and educational activities designed to foster additional collaborations among aging and cancer researchers. Funds also would be used to hire new faculty in basic science and clinical research whose backgrounds and expertise bridge areas identified as promising for collaboration. In addition, funds would be used to establish a new shared resource in Health Outcomes Measurement that is likely to be used by numerous funded investigators conducting aging and cancer research, and to enhance existing shared resources providing biostatistical support and support for the conduct of clinical trials. Letters of commitment included in the application document the strong support of the senior leadership of the Moffitt Cancer Center for this effort. Consistent with the goals of the RFA, receipt of this award is expected to lead to the development of an Aging and Cancer Research Program that will merit incorporation into future Cancer Center Support Grant applications by the Moffitt Cancer Center.