NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 国家老龄研究所(NIA)为ONPRC的100名老年(17岁以上)非人类灵长类动物提供每日支持，该群体被称为灵长类衰老研究(PAS)。PAS群体的目标是为研究人员提供一个模型系统，在其中探索人类衰老和疾病的潜在机制。这些动物都是来自印度的恒河猴，其中大多数是雌性，这反映了后宫的繁殖实践。管理群体平衡预测，以便在研究项目中立即使用，并在必要时通过跟踪和招募中年候选人来确保持续的替换。这是通过与动物资源司的调查人员和动物群体经理进行接触来完成的。整个殖民地问题通过动物利用委员会进行讨论。PAS管理的其他方面还包括收集、存档和分发被扑杀的动物的组织标本，向NIA报告PAS的使用情况，并就研究中使用的老化灵长类动物问题向NIA提供意见。国家关注的问题通过NIA生物资源和资源开发办公室主任Nancy Nadon博士亲自(神经科学学会，2008年，华盛顿特区)以及通过电话和电子邮件进行协调。2008年在科罗拉多州博尔德举行的AGE会议上，与ONPRC以外的研究人员进行了一次讨论，后者也在非人类灵长类动物中进行衰老研究。老龄化资源的另一个作用是收集、存档组织并将其分发给当地和全国的科学家(例如-见印刷论文)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. The animals are all Indian-derived, rhesus macaques with the majority being females, reflecting harem breeding practices. Management of the colony balances prognostication for immediate future use in research projects and ensuring continual replacement by tracking and enrolling middle-aged candidates, as necessary. This is accomplished by interfacing with investigators and animal colony manager in the Division of Animal Resources. Overall colony issues are discussed through the Animal Utilization Committee. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. National concerns are coordinated through the Head of the NIA Office of Biological Resources and Resource Development, Dr. Nancy Nadon, either in person (Society for Neuroscience, 2008, Washington DC) and by phone calls and e-mail. A discussion with investigators outside of ONPRC, who also conduct aging research in nonhuman primates, was held at the AGE meeting held in Boulder, CO in 2008. Another role of the Aging Resource is the collection, archiving and distribution of tissue to scientists both locally and nationally (eg- see paper in press).