EVALUATION OF NOVEL COATING OF METAL OXIDES IN A BABOON ARTERIO-VENOUS SHUNT MOD

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项目将在狒狒动静脉分流模型中评价金属氧化物新型涂层上的血栓形成。该模型已广泛用于评价人工表面和心血管器械，并已证明其在定量表面上血栓形成和生长的重现性方面具有优势。狒狒在涉及血小板和血浆凝血因子的分子活化和抑制途径方面与人类非常相似，因此在这些材料的临床前评价中发挥重要作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will evaluate thrombus formation on novel coatings for metal oxides in the arterio-venous baboon shunt model. This model has been used extensively in the evaluation of artificial surfaces and cardiovascular devices and has proven to be advantageous in its reproducibility in quantifying thrombus development and growth on surfaces. The baboon closely resemble humans with respect to molecular activation and inhibitory pathways involving platelets and plasma coagulation factors and therefore serve an important role in pre-clinical evaluation of these materials.