BETA CELL FUNCTION ACHIEVED BY HEMI-PANCREATECTOMY WITH THE HYPERGLYCEMIC CLAMP

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在空腹血糖水平无异常且HbA 1c正常的胰岛素敏感性年轻雌性狒狒中，检查胰岛素分泌需求急性增加（通过半胰腺切除术，HPx实现）对<$-细胞功能的影响和适应机制（适应vs失代偿）。这种增加的胰岛素分泌需求将在HPx之前和之后通过高血凝钳夹产生。所获得的数据将被用作初步发现，以申请一个名为“狒狒和人类胰岛细胞适应压力的机制”的RO 1，我们打算在2007年2月1日发送给NIH。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To examine the effects and adaptive mechanisms (adaptation vs decompensation) of an acute increase in insulin secretory demand (achieved with hemipancreatectomy, HPx ) on the ¿-cell function, in insulin sensitive young female baboons without abnormalities in fasting glucose levels and normal HbA1c. Such increased insulin secretory demand will be created by the hyperglycaemic clamp before and after the HPx. The data obtained will be used as preliminary findings to apply for an RO1 named "Mechanisms of ¿-cell adaptation to stress in baboon and human pancreatic islets" we intend to send to NIH this coming February 1st, 2007.