CHARACTERIZATION OF NHPS DISPLAYING PHENOTYPES OF HUMAN DISEASES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 与代谢相关的疾病，如肥胖、糖尿病和冠心病，在现代环境中是对公共健康的主要威胁。建立这些疾病的可靠动物模型，如非人类灵长类动物，对于进一步了解它们的触发因素和这些疾病的自然历史是至关重要的。归根结底，这一认识的增加应导致针对这些常见的人类疾病制定干预措施或预防措施。由于恒河猴在基因和生理上与人类相似，因此是进行此类研究的理想动物。在目前的研究中，我们将从40只成年雌性恒河猴队列中收集单一的血液和尿样，以及体重和脂肪分布的测量。我们将使用血液和尿样来测量血糖和血脂水平等基本参数。本研究产生的数据将与从其他猕猴群体收集的类似数据汇集在一起，以便产生关于这些重要代谢参数变化的基本比较数据，这些参数已知与人类各种慢性代谢性疾病的风险有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Metabolically related diseases such as obesity, diabetes, and coronary heart disease represent major threats to public health in the modern environment. The establishment of solid animal models, such as non-human primates, of these diseases is paramount in furthering our understanding of their triggers and natural history of these conditions. Ultimately this increased understnding should lead to the development of interventions or preventions for these common human diseases. Because of its genetic and physiological similarity to humans, the rhesus macaque is an ideal animal for such studies. For the current study we will collect a single blood and urine sample along with measures of body weight, and fat distribution from a cohort of 40 adult female rhesus monkeys. We will use the blood and urine samples to measure basic parameters such as glucose and lipid levels. The data generated from the present study will be pooled with similar data collected from other colonies of rhesus monkeys in order to generate basic comparative data on variation in these important metabolic parameters which are know to be associated with risk for a variety of chronic metabolic diseases in humans.