MAPPING EARLY NETWORK DYSFUNCTION IN FTD AND AD

这项名为《绘制FTD和AD早期网络功能障碍图谱》的项目将开发新的网络 旨在提高额颞部痴呆早期发现和诊断水平的连通性分析 (FTD)和阿尔茨海默病(AD)。正常的认知和行为功能需要协调的活动， 在大规模的分布式网络中。来自人类研究和动物疾病模型的新兴数据 提示在神经退行性变的初期，特定的网络可能会形成早期的、明显的异常。 疾病。为了探索这种可能性，我们将使用功能连接磁共振成像(FcMRI)和扩散光谱 对60例FTD患者、20例无症状FTD基因突变携带者、15例FTD患者进行DSI研究。 AD组和30例健康对照组。我们假设网络连接映射将把每个临床 综合症到特定的内在大脑网络，将被证明能够发现早期疾病，并将提供 对症状发病机制的新见解。我们的目标是(1)在FTD的早期阶段发现网络更改 和AD，(2)比较fcMRI、DSI和常规结构MRI检测网络水平的能力 症状前FTD基因突变携带者的功能障碍；(3)FTD和AD症状与 网络连接中断。所获得的知识可能会为实现一种新颖的、非 早期FTD和AD的侵入性成像生物标志物，并阐明FTD、AD和其他疾病的网络基础 在网络层面以大脑为目标的神经精神障碍。 相关性(请参阅说明)： 该项目将调查额颞叶痴呆和阿尔茨海默氏症患者特定的大脑网络被破坏 疾病。这项研究的目标是使用神经成像来阐明这些疾病在大脑中的起始位置。 以及网络功能障碍如何导致症状。如果进一步发展，这些方法可能会在早期得到改进 检测和诊断，并为跟踪治疗效果提供敏感的生物标志物。

This project, entitled "Mapping Early Network Dysfunction in FTD and AD" will develop novel network connectivity analyses with the goal of improving early detection and diagnosis of frontotemporal dementia (FTD) and Alzheimer's disease (AD). Normal cognitive and behavioral functions require coordinated activity, within large-scale, distributed networks. Emerging data from human studies and animal disease models suggest that specific networks may develop early, tell-tale aberrations during incipient neurodegenerative disease. To explore this possibility, we will use functional connectivity MRI (fcMRI) and diffusion spectral imaging (DSI) to study 60 patients with FTD, 20 asymptomatic FTD gene mutation carriers, 15 patients with AD, and 30 healthy controls. We hypothesize that network connectivity mapping will link each clinical syndrome to a specific intrinsic brain network, will prove capable of detecting early disease, and will provide new insights into symptom pathogenesis. Our aims are (1) to detect network alterations in early stage FTD and AD, (2) to compare the ability of fcMRI, DSI, and conventional structural MRI to detect network-level dysfunction in presymptomatic FTD gene mutation carriers, and (3) to correlate FTD and AD symptoms with network connectivity disruption. The knowledge gained could provide a first step toward a novel, non- invasive imaging biomarker for early FTD and AD and clarify the network basis for FTD, AD, and other neuropsychiatric disorders that target the brain at the network level. RELEVANCE (See instructions): This project will investigate the specific brain networks disrupted in frontemporal dementia and Alzheimer's disease. The goal of the research is to use neuroimaging to clarify where in the brain these diseases begin and how network dysfunction leads to symptoms. Further developed, these methods could improve early detection and diagnosis and provide a sensitive biomarker for following the effects of treatment.