Psychotherapy Development Research Center

描述(由申请人提供)：我们寻求更新我们的心理治疗发展研究中心(PDC)，致力于药物滥用心理治疗的开发、评估和社区应用。组织的主题是心理治疗的发展和基于心理治疗研究的阶段模型(Rounaville，Carroll&Onken，2001)的实证检验。PDC的目标是推动创新的药物滥用治疗方法的发展，从仅仅是“好主意”到能够广泛用作经验性支持的治疗方法(EST)。在PDC支持的10-14年中，我们成功地实施了最初提出的4个成分研究项目，完成了11个试点项目，并指导了多名新的研究人员开发他们的第一个外部支持的行为治疗研究项目。主要发现包括支持PDC开发的干预措施的有效性，包括计算机提供的认知行为治疗(CBT4CBT)版本，针对青少年吸烟者的学校应急管理(CM)计划，以及针对可卡因滥用的适应性提供的基于奖的CM版本。我们还通过为耶鲁大学以外的50个资助项目提供咨询，参与18个多点行为和/或药物治疗疗效试验，开发计算机辅助培训包以促进更广泛地使用有效的药物滥用治疗，并就与行为治疗研究相关的问题向众多国家和国际政府组织和团体提供咨询，成为全国心理治疗研究的资源。在过去的四年里，我们的研究越来越多地关注执行功能受损和冲动作为成瘾的基本组成部分和干预的潜在目标所起的作用。这项工作需要扩大我们的神经认知评估单元，并在试点和组件研究中纳入创新的fMRI神经成像范式。在更新期间，将继续围绕阶段模式组织研究，包括一个核心设施和3个组成部分项目。核心工作人员将监督一项雄心勃勃的试点研究计划，并为中心项目提供科学监督、管理、标准化的心理和神经生物学评估和技术援助，以及向其他地点的研究人员和临床医生提供咨询和帮助。三个晚期II组分临床试验将检验(1)将CBT4CBT与一种认知增强药物相结合，(2)针对可卡因依赖的基于奖的CM的最佳序列，以及(3)在以学校为基础的戒烟计划中将以学校为基础的CM与尼古丁替代疗法相结合。 中心特征

DESCRIPTION (provided by applicant): We seek to renew our psychotherapy development research center (PDC) dedicated to the development, evaluation and community application of psychotherapies for drug abuse. The organizing theme is psychotherapy development and empirical testing based on the Stage Model (Rounsaville, Carroll & Onken, 2001) of psychotherapy research. The PDC's goal is to catalyze the development of innovative drug abuse treatments from the point where they are merely "good ideas" to one where they are capable of widespread use as empirically supported treatments (EST's). In years 10-14 of PDC support we have successfully conducted the 4 originally proposed component research projects, completed 11 pilot projects and guided multiple new investigators to develop their first externally supported research projects on behavioral treatments. Key findings include support for efficacy of PDC developed interventions including a computer delivered version of Cognitive Behavioral Therapy (CBT4CBT), a school based Contingency Management (CM) program for adolescent smokers and an adaptively delivered version of Prize Based CM for cocaine abuse. We have also served as a national resource for psychotherapy research by consulting on 50 funded projects outside Yale, participating in 18 multisite behavioral and/or pharmacotherapy efficacy trials, developing computer-assisted training packages to foster more widespread use of efficacious substance abuse treatments and providing consultation on issues related to behavioral therapies research to numerous national and international government organizations and groups. In the past 4 years our research has been increasingly focused on examining the role of impaired executive functioning and impulsivity as fundamental components of addiction and as potential targets for interventions. This work has entailed expanding our neurocognitive assessment battery and incorporating an innovative fMRI neuroimaging paradigm in pilot and component studies. During the renewal period, research will continue to be organized around the Stage Model with a CORE facility and 3 component projects. Core staff will oversee an ambitious pilot study program and provide scientific oversight, administration, standardized psychological and neurobiological assessments, and technical assistance to center projects along with consultation and assistance to investigators and clinicians at other sites. Three late Stage II component clinical trials will examine (1) combining CBT4CBT with a cognitive-enhancement medication, (2) optimal sequences of Prize Based CM for cocaine dependence and (3) combining school based CM with nicotine replacement therapy in a school based cigarette cessation program. CENTER CHARACTERISTICS