IMMUNOGENETICS AND FUNCTIONAL RESPONSE TO TYPE A INFLUENZA STRAINS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 研究 北极狐和狂犬病感染仍然是一个有吸引力的项目，然而，我的实验室目前仍然非常专注于禽流感。我正在运行这个项目的两个部分，还有两个正在开发中： 1)阿拉斯加禽流感监测。这项多年的努力将作为合作项目的基线数据，以了解禽流感在自然环境和水库宿主中的出现和生态。 A.迄今分析的900个2005年样本摘要--25%呈阳性，5个亚型，无H5N1 2)环境样品中禽类流感与环境中流感阳性的相关性。 A.分析的11个样本中有9个显示基质和NP阳性 正在开发中： 1)野生鸟类的免疫遗传学研究： 免疫相关基因的遗传特征。 2)免疫健康的功能分析

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research The arctic fox and rabies infection remains an attractive project, however, my lab currently remains very focused on avian influenza. I have two parts of this project running and two in development: 1) Avian influenza  surveillance for avian influenza in Alaska. This multiyear effort will serve as baseline data for collaborative projects to understand the emergence and ecology of avian influenza in the natural environment and in reservoir hosts. a. Summary of 900 2005 samples analyzed to date - 25% positive, 5 subtypes, no H5N1 2) Environmental samples  correlation of influenza in birds with influenza positives in the environment. a. 9 of 11 samples analyzed show matrix and np positives In development: 1) Immunogenetic studies in wild birds: Genetic characterization of immune relevant genes. 2) Functional assays of immune health