THE ROLE OF C/EBPS IN ALZHEIMER'S DISEASE INFLAMMATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Strohmeyer博士目前的研究兴趣是研究转录因子家族，该家族在调节阿尔茨海默病(AD)的几个感兴趣的细胞程序方面发挥核心作用。这个家族被称为CCAAT/增强子结合蛋白(C/EBPs)，有六个成员。Strohmeyer博士目前正专注于研究C/EBPs在调节大脑小胶质细胞中炎症基因表达方面的作用。已知小胶质细胞在脑部炎症过程中表达C/EBPs，并有望在这些细胞中调节这一过程。斯特罗迈耶博士的研究目标是证明这一点，并确定阿尔茨海默病的经典标志淀粉样蛋白b是否诱导小胶质细胞中C/EBPs的激活。通过进行进一步了解这些过程的研究，我们可能获得新的见解，这些见解可能被证明对阿尔茨海默氏症和其他具有炎症成分的神经退行性疾病的治疗有用。 斯特罗迈耶博士的研究目前包括以下四个详细目标： 研究C/EBP各亚型在人脑组织和小胶质细胞系培养中的表达模式。 评估C/EBPs在小胶质细胞系培养中调节细胞因子、趋化因子、补体、iNOS和其他炎症基因表达的功能。 评估C/EBPs在小胶质细胞活化和分化中的作用，以响应炎症刺激和b淀粉样蛋白。 ？确定C/EBPS是否可能受到抗炎药物的调节，如非类固醇抗炎药(NSAIDs)(即布洛芬)、统称为他汀类的降胆固醇药物，以及天然化合物(如植物多酚)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Strohmeyer's current research interests are in studying a transcription factor family that plays a central role in regulating several cellular programs of interest in Alzheimer's disease (AD). This family is known as the CCAAT/Enhancer Binding Proteins (C/EBPs) and has six members. Dr. Strohmeyer is currently focusing on studying the role of C/EBPs in regulating the expression of inflammatory genes in microglia cells in the brain. Microglia are known to express C/EBPs during brain inflammation and are expected to regulate this process in these cells. Dr. Strohmeyer's research objective is to show this to be the case and to determine whether amyloid b, a classical hallmark of AD, induces the activation of C/EBPs in microglia. By conducting studies that further our understanding of these processes, we may obtain novel insights that might prove to be therapeutically useful in Alzheimer's and other neurodegenerative diseases having an inflammatory component. Dr. Strohmeyer's research currently encompasses the following four detailed objectives: ¿ Characterizing the expression pattern of each C/EBP isoform in human brain tissue and in microglia cell line cultures. ¿ Assessing the functionality of C/EBPs in modulating the expression of cytokine, chemokine, complement, iNOS, and other inflammatory genes in microglia cell line cultures. ¿ Assessing the role of C/EBPs in microglial cell activation and differentiation in response to inflammatory stimuli and b amyloid protein. ¿ Determining whether C/EBPs may be modulated by anti-inflammatory drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) (i.e. ibuprofen), cholesterol-lowering drugs collectively known as statins, and natural compounds such as plant-derived polyphenols.