ELUCIDATING SIGNALING MECHANISMS IN PLATELETS AND MEGAKARYOCYTES

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我的研究围绕着两个独立的研究领域。 第一个领域旨在阐明一些影响新血小板形成的细胞外和细胞内信号。 具体来说，我的实验室研究了信号如何促进称为巨核细胞的血小板前体细胞形成长丝状链。 这些长链称为前血小板，被认为是血小板组装和释放的场所。 然而，很少有人知道什么样的事件是必要的前血小板形成。 第二个领域研究了一类称为小GTP酶的蛋白质在血小板与细胞外基质结合时的变化，这是血小板介导的止血和伤口愈合的关键事件。 这些GTP酶充当控制信号从血小板外到血小板内的运动的分子开关，并在血管损伤后指示血小板的生理变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. My research revolves around two separate areas of study. The first area aims to elucidate some of the extracellular and intracellular signals that influence the formation of new platelets. Specifically, my lab examines how signals promote the formation of long filamentous strands from platelet-precursor cells called megakaryocytes. These long strands, called proplatelets, are thought to be the site of platelet assembly and release. However, very little is known about what events are necessary for proplatelets to form. The second area examines the changes in a class of proteins called small GTPases in response to platelet binding to extracellular matrices, a critical event in platelet-mediated hemostasis and wound healing. These GTPases serve of molecular switches that control the movement of signals from outside of the platelet to within the platelet, and dictate physiological changes to the platelet after injury to the blood vessel.