COBRE for Women in Science & Engineering on Osteoarthritis

描述（由申请人提供）：在本申请中，我们建议提供一个多学科平台，指导科学和工程（WISE）中的女性在骨关节炎研究中取得成功。这是建立在我们的第一个生物医学研究卓越中心（COBRE）关于骨关节炎（OA）的奖项的基础上。在这个应用程序中的每个项目是由一名女教师和所有初级教师将有科学导师和职业导师，以帮助他们在过渡到成为终身教职与NIH的支持领导。在我们的三管齐下的方法中，我们将建立外部网络，内部辅导和大学范围内的计划，以提高机构对性别问题的认识。这个COBRE奖通过我们在特拉华州大学的生物医学工程研究中心（CBER）运作。该中心的目标是建立基础设施和专业知识基础，以解决OA的机制，以及其预防和治疗。我们中心采用的方法的独特性将是从生物化学，组织力学，生物力学，物理治疗和临床干预的综合，多学科转化的角度来检查OA。一些核心科学领域的专业知识，在拟议的程序是完善的特拉华州的大学，但他们一直在传统上分散在不同的实验室在不同的部门，并有最低限度的参与初级教员。在我们提出的工作中，我们将建立在CBER的独特组织基础上，该组织是通过COBRE奖和本申请中描述的合作项目建立的。将在该中心下开展五个分项目。子项目是多学科的，参与者来自工程学院，艺术与科学学院和健康科学学院的多个学术单位。项目名称为（1）软骨生长和愈合中的串珠素和乙酰肝素酶，（2）骨关节炎关节软骨下骨板中的溶质转运，（3）膝关节骨关节炎进展的风险因素，（4）全膝关节置换术（TKA）后关节负荷和骨关节炎进展，以及（5）膝关节僵硬、本体感觉和不稳定对OA膝关节控制的影响。

Description (provided by applicant): In this application, we propose to provide a multidisciplinary platform for mentoring women in science and engineering (WISE) to have sucessful careers in osteoarthritis research. This builds on the work of our first Center of Biomedical Research Excellence (COBRE) award on osteoarthritis (OA). Each project in this application is led by a women faculty member and all junior faculty will have scientific mentors and career mentors to help them in the transition to becoming tenured faculty with NIH support. In our three-pronged approach, we will extablish external networks, internal mentoring, and university-wide programs to increase institutional awareness of gender issues. This COBRE award operates through our Center for BiomedicalEngineering Research (CBER) at the University of Delaware. The aim of the Center is to create theinfrastructure and expertise base to address the mechanisms of OA, as well as its prevention and treatment.The uniqueness of the approach to be employed by our center will be the examination of OA from theintegrated, multidisciplinary translational perspectives of biochemistry, tissue mechanics, biomechanics,physical therapy and clinical intervention. Some of the core scientific areas of expertise in the proposedprogram are well-established at the University of Delaware, but they have traditionally been spread acrossdifferent laboratories in different departments and have minimal involvement of junior faculty members. In the context of our proposed work, we will build upon the distinctive organization of CBER established with the COBRE award and the collaborative projects described in this application. Five subprojects will be carried out under the Center umbrella. The subprojects are multidisciplinary and the participants are drawn from multiple academic units in the Colleges of Engineering, Arts & Sciences, and Health Sciences. The projecttitles are (1) Perlecan and Heparanase in Cartilage Growth and Healing, (2) Solute Transport in theSubchondral Bone Plate of Osteoarthritic Joints, (3) Risk Factors for Progression of Osteoarthritis of the Knee, (4) Joint Loading and the Progression of Osteoarthritis following Total Knee Arthroplasty (TKA), and (5) Knee Stiffness, Proprioception and Instability affect Knee Control in OA.