COBRE: U KS: CORE A: ADMINISTRATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 拟议的COBRE计划的总体目标是建立一个多学科研究中心，专注于使用现有的最佳实验策略来探测目标蛋白质的结构和功能特性。该中心将提供密集的指导和一流的研究环境，以提高在劳伦斯的堪萨斯大学（KU-L），堪萨斯城的堪萨斯大学医学中心（KUMC），曼哈顿的堪萨斯州立大学（KSU）和威奇托的威奇托州立大学（WSU）的蛋白质化学和生物学接口工作的几个初级教师的竞争力。参与的教师来自不同的部门，但他们都对理解特定蛋白质的结构及其在细胞生物学中的功能作用之间的关系有着浓厚的兴趣。初级教师参与者和高级指导教师所代表的专业知识涵盖了从质谱和蛋白质晶体学到微生物发病机制和细胞分化调控的广泛范围。然而，所有参与者都强烈希望将有效的现代技术和实验策略应用于重要蛋白质的表征。我们的具体目标是：目标1。建立一个蛋白质结构和功能的生物医学研究卓越中心，与蛋白质组学和蛋白质化学和生物学的其他区域努力协同作用。 目标2.在四个机构中组织一批成熟的、由NIH资助的教师，他们将担任蛋白质结构和功能领域最近聘用和即将聘用的教师的导师，并支持5  初级教师的6个独立研究项目，以综合，多学科的方式从生物学和化学的角度解决蛋白质结构和功能的重大问题。在5年的时间里，COBRE计划将帮助至少15名新教师开发蛋白质结构和功能方面极具竞争力的研究项目。 目标3：通过建立科学核心，提供专业知识和仪器，支持蛋白质结构和功能的研究，加强蛋白质结构和功能最先进研究的整体基础设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the proposed COBRE program is to establish a multidisciplinary research center focused on the use of the best experimental strategies available to probe the structural and functional properties of targeted proteins. The Center will provide intensive mentoring and superb research environments to enhance the competitiveness of several junior faculty working at the interface of protein chemistry and biology at University of Kansas in Lawrence (KU-L), University of Kansas Medical Center in Kansas City (KUMC), Kansas State University in Manhattan (KSU), and Wichita State University in Wichita (WSU). Participating faculty are based in a variety of departments, but they all share a strong interest in understanding the relationship between the structure of a specific protein and its functional role in the biology of the cell. The expertise represented by both the junior faculty participants and the senior mentoring faculty spans a broad range from mass spectrometry and protein crystallography to microbial pathogenesis and regulation of cell differentiation. However, all participants are united by a strong desire to apply effective modern technologies and experimental strategies to the characterization of important proteins. Our specific aims are: Aim 1. To establish a Center of Biomedical Research Excellence in Protein Structure and Function that will synergize with other regional efforts in proteomics and protein chemistry and biology. Aim 2. To organize a core of well-established, NIH-funded faculty members across the four institutions who will serve as mentors for recently hired and to-be-hired faculty in the area of protein structure and function, and to support 5  6 independent research programs of junior faculty addressing significant problems in protein structure and function from a biological as well as chemical perspective in an integrated, multidisciplinary way. Over the 5-year period the COBRE program will assist at least 15 new faculty in developing highly competitive research programs in protein structure and function. Aim 3. To enhance the overall infrastructure for state-of-the-art research in protein structure and function through establishment of scientific cores that provides expertise and instrumentation in support of research in protein structure and function.