AGE MODERATES HIV-RELATED CNS DYSFUNCTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在艾滋病毒/艾滋病流行的过程中，有一个不变的事实-所有新病例的10%发生在50岁以上的成年人中。 尽管如此，绝大多数艾滋病毒/艾滋病研究都集中在50岁以下的人身上。随着艾滋病患者存活率的提高和新感染/病例的不断增加，50岁以上的艾滋病患者人数正在增加。我们对年龄和艾滋病毒/艾滋病如何相互作用缺乏了解，这一点正变得越来越成问题，在艾滋病的神经认知表现方面也是如此，因为年龄本身就是神经认知综合征的一个重要预测因素。尽管已知年龄与包括痴呆症在内的各种神经精神疾病之间存在联系，但直到最近，人们才对艾滋病毒/艾滋病与衰老和神经精神病表现之间可能的相互作用给予了更多关注。本研究的目的是比较和对比神经心理缺陷，包括与艾滋病毒/艾滋病相关的脑结构和功能异常作为实足年龄的函数。 特别是，我们将描述老年艾滋病患者的神经影像学和神经心理学缺陷，重点是两种不同的神经病理学，可导致损害-一个通过内侧颞叶功能障碍（衰老），另一个通过基底神经节功能障碍（艾滋病）。通过仔细描述神经心理缺陷（包括使用脑成像技术确定的缺陷），我们将能够更好地了解衰老和艾滋病毒/艾滋病的相互影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the course of the HIV/AIDS epidemic there has been one constant - ten percent of all new cases occur in adults over the age of 50. In spite of this, the vast majority of all HIV/AIDS research has focused on individuals younger than 50. With the increasing survival of AIDS patients, and the unrelenting rate of new infection/cases, the number of AIDS patients over 50 years of age is growing. Our lack of understanding about how age and HIV/AIDS interact is becoming increasingly problematic, no more so than in the area of the neurocognitive manifestations of AIDS, since age is itself an important predictor of neurocognitive syndromes. In spite of the known links between age and various neuropsychiatric disorders - including dementia - it has only been recently that much attention has been paid to the possible interactions between HIV/AIDS and aging and neuropsychiatric presentation. The purpose of this study is to compare and contrast neuropsychological deficits, including brain structural and functional abnormalities associated with HIV/AIDS as a function of chronological age. In particular, we will characterize the neuroimaging and neuropsychological defects in older individuals with AIDS focusing on two distinct neuropathologies that can lead to impairment - one via mesial temporal dysfunction (aging), and the other via basal ganglia dysfunction (AIDS). By carefully characterizing the neuropsychological deficits (including those identified using brain imaging technology) we will be better able to understand the interactive effects of aging and HIV/AIDS.