Semi-volatile PCBs: Sources, Exposures, Toxicities

描述（由申请人提供） 爱荷华州大学的超级基金基础研究项目（ISBRP）是一项共同奋进，涉及生物医学和非生物医学研究领域的基础、机械和应用项目。该方案的总主题是大气来源和接触半挥发性多氯联苯的后果，它涉及低卤化多氯联苯的挥发、运输和接触，特别是那些与受污染的沃茨、前工业场地、其他大气来源有关的多氯联苯，以及接触这些物质的后果。我们计划确定接触途径，以防止或限制接触并改善影响。ISBRP汇集了15名科学家，代表4所学院的5个部门。他们将共同努力，测量多氯联苯的来源、运输和环境接触（项目4和6）;其在动物和人类中的分布、代谢和毒性（项目1、2和3）;以及植物补救的新方法（项目5）。研究包括一个以社区为基础的参与性研究项目-评估在芝加哥大都市区低氯化多氯联苯来源附近生活或工作的公民的接触情况。我们享受着芝加哥公民团体的合作，那里许多少数民族公民在非工业化地区附近生活在贫困线以下。我们的研究项目和整体效率由七个核心支持-管理，合成，分析，吸入毒理学，培训，研究翻译和社区外展-通过这些计划和项目管理员将监督协调，信息传输，实验设计和分析，以及研究评估。评估过程在我们8人外部咨询委员会的年度会议上达到高潮。合成核心将合成所有待研究的化合物/混合物，而分析核心提供从代谢到运动的关键成分信息。社区外展和研究翻译中心将把研究结果传递给各种利益攸关方，并让这些利益攸关方参与研究活动。一个培训核心和研究项目提供了20多名学生和博士后学者的培训。总的来说，这个多学科的计划带来了国外的经验和专业知识，以承担与超级基金化学品，是至关重要的中西部和国家相关的问题。

DESCRIPTION (provided by applicant) The Superfund basic research program at the University of Iowa (ISBRP) is a joint endeavor involving basic, mechanistic and applied projects in biomedical and non-biomedical research areas. The program's overall theme is the consequences of atmospheric sources and exposures to semi-volatile Polychlorinated Biphenyls (PCBs), and it deals with volatilization, transport and exposure of lower halogenated PCBs, especially those PCBs that are associated with contaminated waters, former industrial sites, other atmospheric sources, and the consequences of exposure to them. We plan to identify routes of exposure with an eye to preventing or limiting exposure and ameliorating the effects. The ISBRP brings together 15 scientists, representing 5 departments in 4 colleges. Working together, they will measure sources, transport and environmental exposure of PCBs (project #4 and #6); their distribution, metabolism and toxicity in animals and humans (project #1, #2 and #3); and novel methods of phytoremediation (project #5). Studies include a community-based participatory research project-an assessment of exposures to citizens who live or work in the vicinity of sources of lower chlorinated PCBs in the Chicago Metropolitan area. We enjoy the cooperation of citizen groups in Chicago, where many ethnic-minority citizens are living below the poverty line near deindustrialized sites. Our research projects and overall efficiency are supported by seven cores- Administration, Synthesis, Analytical, Inhalation Toxicology, Training, Research Translation and Community Outreach -through which program and project administrators will oversee coordination, information transfer, design and analysis of experiments, and assessment of research. The assessment process culminates in an annual meeting of our 8-member External Advisory Committee. The Synthesis Core will synthesize all compounds/mixtures to be studied while the Analytical Core provides critical compositional information from metabolism to movement. Community Outreach and Research Translation Cores will transmit research findings to a variety of stakeholders and involve those stakeholders in research activities. A Training Core and the research projects provide for the training of more than 20 students and postdoctoral scholars. Overall this multidisciplinary program brings abroad range of experience and expertise to bear on problems associated with Superfund chemicals that are critical to the Midwest and the nation.