Michigan Alzheimer's Disease Research Center

描述（申请人提供）：密歇根阿尔茨海默病研究中心。这是一份竞争性继续申请的重新提交，以启动三个新的科学项目，继续试点拨款计划，并支持由NIH额外拨款资助的痴呆症的多项科学研究，利用五个核心，行政，临床，数据管理和统计，神经病理学，教育和信息。这些项目调查阿尔茨海默病（AD），其中两个项目关注轻度认知障碍和早期痴呆。项目1利用转基因和敲除小鼠研究了XI1 α对淀粉样蛋白前体蛋白切割抑制作用的机制，并探测了XI1 α与9号染色体的遗传连锁。项目2确定PET与[18F]FDG是否可以预测MCI和早期痴呆的痴呆进展速度。项目3评估PET与[11C]DTBZ在预测早期痴呆发展为临床表现的AD、路易体痴呆和额颞叶痴呆的疗效。少数民族卫星诊断和治疗中心将继续招募代表性不足的城市患者，主要是非裔美国人，进行研究。这些方法利用了密歇根大学神经学和神经科学的主要优势，包括大量正常老年受试者，MCI和AD患者，尸检验证的纵向研究，生物统计学，PET，分子生物学和分子药理学。MADRC为实现其科学和教育目标，特别是医学院、公共卫生学院和护理学院，与该大学的多个组成部分进行互动；社会研究所；克劳德佩珀中心，内森休克中心，老年学研究所，老年研究教育和临床中心在安娜堡退伍军人事务医疗中心。它在研究项目上与其他adc合作，并在数据共享方面与NACC合作。它在全州范围内的痴呆症倡议中发挥领导作用，并与阿尔茨海默病协会的国家和地方分会密切合作。它为吸引研究员、初级和高级科学家从事前沿的基础和临床研究提供了丰富的环境。

DESCRIPTION (provided by applicant): Michigan Alzheimer's Disease Research Center. This is the resubmission of a competing continuation application to initiate three new scientific projects, continue a pilot grants program, and support multiple scientific investigations of the dementias funded through additional NIH grants utilizing five cores, Administrative, Clinical, Data Management and Statistics, Neuropathology, and Education and Information. The projects investigate Alzheimer's disease (AD), and two focus on MCI and early dementia. Project 1 examines mechanisms underlying the inhibitory effects of XI1 alpha upon cleavage of amyloid precursor protein utilizing transgenic and knockout mice and probes the genetic linkage of XI1 alpha to chromosome 9. Project 2 determines whether PET with [18F]FDG can predict the rate of progression of dementia in MCI and early dementia. Project 3 evaluates the efficacy of PET with [11C]DTBZ in predicting the evolution of early dementia into clinically distinguished AD, dementia with Lewy bodies, and frontotemporal dementia. A minority satellite diagnostic and treatment center will continue to recruit underrepresented urban, predominantly African American, patients to research studies. The approaches utilize major strengths in neurology and neuroscience at the University of Michigan, including the availability of large numbers of normal aged subjects, patients with MCI and with AD, longitudinal studies with autopsy verification, biostatistics, PET, molecular biology, and molecular pharmacology. The MADRC interacts with multiple components of the University for its scientific and educational objectives, particularly the Schools of Medicine, Public Health, and Nursing; Institute for Social Research; Claude Pepper Center, Nathan Shock Center, Institute of Gerontology, and Geriatric Research Education and Clinical Center at the Ann Arbor Veterans Affairs Medical Center. It collaborates with other ADCs on research projects and with NACC in data sharing. It plays a leadership role in statewide dementia initiatives and works closely with national and local chapters of the Alzheimer Association. It provides a rich environment for attracting fellows, junior and senior scientists into cutting-edge basic and clinical research.