OPTIMIZING HYPERPOLARIZATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 目前的超极化方法需要60 - 90分钟来制备样品。 这种延迟显著降低了该方法的生物学和临床实用性，因为它阻止了对干预的快速变化或响应的研究。 Merritt博士开发了快速极化的新方法，将在高风险，高影响机构基金的支持下进行研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Current methods for hyperpolarization require 60 - 90 minutes to prepare the sample. This delay significantly degrades the biological and clinical utility of the method since it prevents study of rapid changes or responses to interventions. Dr. Merritt has developed new approaches to rapid polarization that will be investigated with support from high-risk, high impact institution funds.