FOURIER DOMAIN LOW COHERENCE INTERFEROMETRIC MICROSCOPY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在开发一种傅里叶域位相显微镜(FDPM)，用于细胞电动的反射模式研究。FDPM使用宽带光源和公共路径相位基准检测方案，允许以埃尺度灵敏度在千赫带宽对细胞位移进行深度分辨测量。SDPM的低噪声和高灵敏度将使测量细胞对单位脉冲刺激的响应成为可能。还可以通过优选地扫描样本光束来执行二维成像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing a Fourier domain phase microscope (FDPM) for reflection-mode studies of cell electromotility. The FDPM uses a broadband light source together with a common-path phase-referenced detection scheme to allow depth resolved measurements of cell displacements at kHz bandwidths with angstrom-scale sensitivity. The low-noise and high sensitivity of SDPM will make it possible to measure the cell response to a unit impulse stimulus. Two-dimensional imaging can also be performed by preferably scanning the sample beam.