SIMULTANEOUS MEASUREMENTS OF ADC AND PO2

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 近年来，超极化氦-3磁共振成像(HP-3He MRI)得到了广泛的应用 广泛用于肺结构和功能参数的定量评估。 最小空间尺度的肺泡大小和气道形态可以用HP 3He磁共振来阐明 表观扩散系数(ADC)成像。肺氧量测量，这是一种 功能成像示例，产生局部肺泡氧分压(PO2)和耗竭率 (ODR)。在我们以前的工作中，我们提出了一种基于多元回归的单次收购 同时测量ADC、PO2和ODR的技术。在这个项目中，我们扩展了这一点 技术，并提出了一种新的捕获方案，该方案还包括 区域空气交换效率，称为分数通气量(R)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recent years, hyperpolarized helium-3 magnetic resonance imaging (HP 3He MRI) has been used extensively for quantitative assessments of pulmonary structural and functional parameters. Alveolar size airway morphology at the smallest spatial scales can be elucidated using HP 3He MR apparent diffusion coefficient (ADC) imaging. The pulmonary oxygen measurement, which is an example of functional imaging, yields regional alveolar oxygen tension (pO2) and depletion rate (ODR). In our previous work, we proposed a multiple-regression-based single acquisition technique for simultaneously measuring ADC, pO2 and ODR. In this project, we expand this technique and present a new acquisition scheme which additionally includes a characterization of regional air exchange efficiency, termed fractional ventilation (r).