THE ROLE OF LHX2 IN MEDIATING CELLULAR ADHESIVE PROPERTIES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们研究了转录因子Lhx 2，以及Lhx 2功能的丧失如何影响细胞粘附。 在Lhx 2无效突变体和同窝对照之间进行短期聚集测定。 聚集体在LFD中通过Z系列中的双通道双光子显微镜成像。 聚集体的3D重建将从Z系列图像生成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We examine the transcription factor, Lhx2, and how loss of Lhx2 function effects cell adhesion. Short-term aggregation assays are performed between Lhx2 null mutant and littermate controls. The aggregates are imaged in the LFD by two-channel, 2-photon microscopy in a Z-series. 3D reconstructions of the aggregates will be generated from the Z-series images.