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Core D-Neuropathology Core

核心 D-神经病理学核心

基本信息

批准号：
10582632
负责人：
EDWIN S MONUKI
金额：
$ 47.31万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10582632
关键词：
Adherence Age Aliquot Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Amyloid beta-Protein Artificial Intelligence Astrocytes Autopsy Award Biological Markers Biology Blood specimen Brain California Catalogs Cd68 Cells Clinical Clinical Data Collaborations Collection Data Set Deposition Diagnosis Diagnostic Disease Doctor of Philosophy Down Syndrome Education Ensure Equipment and supply inventories Faculty Family Fibroblasts Functional disorder Funding Generations Genetic Diseases Glial Fibrillary Acidic Protein Goals Grant Guidelines Harvest Head Health system Hour Individual Infrastructure Institution International Light Link Longevity Magnetic Resonance Imaging Mentorship Methods Microglia Microscopy Minority Morphology National Institute on Alcohol Abuse and Alcoholism Neurons Participant Pathology Performance Practice Guidelines Predisposition Process Protocols documentation Publications Reporting Research Research Personnel Resources Rotation Sampling Services Site Skin Special Population Stains Standardization System Training and Education Universities Visit Work adjudication biobank brain tissue cell type clinical conference clinical trial participant cohort data management digital education research genome wide association study glial activation high risk induced pluripotent stem cell innovation integration site member mixed dementia neuropathology next generation novel operation outreach professor recruit tau Proteins whole slide imaging

项目摘要

PROJECT SUMMARY – NEUROPATHOLOGY CORE (CORE D) The UCI ADRC Neuropathology (NP) Core provides autopsy, diagnostic, and biorepository services for the three cohorts of the UCI ADRC - Uniform Data Set (UDS), 90+, and Down syndrome - which span a broad range of ages and susceptibilities to AD. The overarching goal of the NP Core is to support education, outreach, and research on AD and related disorders (ADRD) in collaboration with other ADRC cores and ADRD researchers to “identify, quantify, and validate factors that influence the risk of AD across the lifespan.” Since its inception, the NP Core has collected and maintained a considerable bank of high-quality biospecimens, which have been distributed broadly to NCRAD and federally-funded local, national, and international ADRD investigators and consortia. Core operations have been continually enhanced, and metrics of core performance are strong. To expand its capacity, three new faculty have joined the NP Core, including a neuropathologist who is also a REC mentee (Mari Perez-Rosendahl). Together with the other UCI ADRC Cores, the NP Core proposes six Aims to enhance its diagnostic, education, and research functions via collaboration, innovation, and education: 1) Provide accurate, timely, comprehensive, and standardized postmortem examinations and diagnostic reports on UDS subjects and special populations, including the addition of postmortem skin collection on selected cases in collaboration with the iPSC Core; 2) Harvest, process, store, catalog, and distribute high-quality brain tissue and biospecimens to ADRD researchers at UCI and beyond, collaborating with the DMS and Biomarker Cores in its data management and biospecimen utilization functions; 3) Incorporate new analysis methods to enable novel microglial studies by UCI investigators at the cutting-edge of a new microglial biology in AD; 4) Incorporate whole slide imaging (WSI) to facilitate diagnoses, research, and education, including the establishment of interfaces with a UC-wide WSI network and UCI artificial intelligence (AI) center; 5) Support novel ADRD research and outreach in collaboration with other UCI ADRC Cores and other ADRCs, including new studies involving postmortem MRI, light sheet microscopy of cleared brain tissues, and AI studies of WSIs; and 6) Contribute unique expertise to the education and training of the next generation of AD clinicians and researchers, including Dr. Perez- Rosendahl, neuropathologist and REC mentee.

项目总结-神经病理学核心（核心d）