Core D-Neuropathology Core

核心 D-神经病理学核心

• 批准号: 10378030
• 负责人: EDWIN S MONUKI
• 金额: $ 33.83万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10378030
• 关键词: Adherence; Age; Aliquot; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease risk; Amyloid beta-Protein; Artificial Intelligence; Astrocytes; Autopsy; Award; Biological Markers; Biology; Blood specimen; Brain; California; Catalogs; Cells; Clinical; Clinical Data; Collaborations; Collection; Data Set; Deposition; Diagnosis; Diagnostic; Diagnostics Research; Disease; Doctor of Philosophy; Down Syndrome; Education; Education and Outreach; Ensure; Equipment and supply inventories; Faculty; Family; Fibroblasts; Functional disorder; Funding; Generations; Genetic Diseases; Glial Fibrillary Acidic Protein; Goals; Gold; Grant; Guidelines; Harvest; Head; Health system; Hour; Individual; Infrastructure; Institution; International; Light; Link; Longevity; Magnetic Resonance Imaging; Mentorship; Methods; Microglia; Microscopy; Minority; Morphology; Neurons; Outreach Research; Participant; Pathology; Performance; Practice Guidelines; Predisposition; Process; Protocols documentation; Publications; Reporting; Research; Research Personnel; Resources; Rotation; Sampling; Services; Site; Skin; Special Population; Stains; Standardization; System; Time; Training and Education; Universities; Visit; Work; adjudication; biobank; brain tissue; cell type; clinical trial participant; cohort; data management; diagnosis standard; digital; education research; genome wide association study; high risk; induced pluripotent stem cell; innovation; integration site; member; mixed dementia; neuropathology; next generation; novel; operation; outreach; professor; recruit; symposium; tau Proteins; whole slide imaging

PROJECT SUMMARY – NEUROPATHOLOGY CORE (CORE D) The UCI ADRC Neuropathology (NP) Core provides autopsy, diagnostic, and biorepository services for the three cohorts of the UCI ADRC - Uniform Data Set (UDS), 90+, and Down syndrome - which span a broad range of ages and susceptibilities to AD. The overarching goal of the NP Core is to support education, outreach, and research on AD and related disorders (ADRD) in collaboration with other ADRC cores and ADRD researchers to “identify, quantify, and validate factors that influence the risk of AD across the lifespan.” Since its inception, the NP Core has collected and maintained a considerable bank of high-quality biospecimens, which have been distributed broadly to NCRAD and federally-funded local, national, and international ADRD investigators and consortia. Core operations have been continually enhanced, and metrics of core performance are strong. To expand its capacity, three new faculty have joined the NP Core, including a neuropathologist who is also a REC mentee (Mari Perez-Rosendahl). Together with the other UCI ADRC Cores, the NP Core proposes six Aims to enhance its diagnostic, education, and research functions via collaboration, innovation, and education: 1) Provide accurate, timely, comprehensive, and standardized postmortem examinations and diagnostic reports on UDS subjects and special populations, including the addition of postmortem skin collection on selected cases in collaboration with the iPSC Core; 2) Harvest, process, store, catalog, and distribute high-quality brain tissue and biospecimens to ADRD researchers at UCI and beyond, collaborating with the DMS and Biomarker Cores in its data management and biospecimen utilization functions; 3) Incorporate new analysis methods to enable novel microglial studies by UCI investigators at the cutting-edge of a new microglial biology in AD; 4) Incorporate whole slide imaging (WSI) to facilitate diagnoses, research, and education, including the establishment of interfaces with a UC-wide WSI network and UCI artificial intelligence (AI) center; 5) Support novel ADRD research and outreach in collaboration with other UCI ADRC Cores and other ADRCs, including new studies involving postmortem MRI, light sheet microscopy of cleared brain tissues, and AI studies of WSIs; and 6) Contribute unique expertise to the education and training of the next generation of AD clinicians and researchers, including Dr. Perez- Rosendahl, neuropathologist and REC mentee.

项目总结-神经病理学核心（核心D） UCI ADRC神经病理学（NP）核心提供尸检，诊断和生物储存服务， UCI ADRC的三个队列-统一数据集（UDS），90+和唐氏综合征-跨越了广泛的 年龄范围和AD易感性。NP核心的首要目标是支持教育， 与其他ADRC核心合作开展AD和相关疾病（ADRD）的外展和研究， ADRD研究人员“识别，量化和验证影响整个生命周期AD风险的因素”。 自成立以来，NP Core已经收集并保持了相当数量的高质量银行 生物标本，已广泛分发给NCRAD和联邦资助的地方，国家， 国际ADRD调查人员和财团。核心业务不断得到加强， 核心业绩强劲。为了扩大其能力，三个新的教师加入了NP核心，包括一个 神经病理学家，也是REC学员（Mari Perez-Rosendahl）。与其他UCI ADRC一起 核心，NP核心提出了六个目标，以加强其诊断，教育和研究功能， 协作、创新和教育：1）提供准确、及时、全面和标准化的 对UDS受试者和特殊人群的尸检和诊断报告，包括 与iPSC核心合作，在选定病例上增加死后皮肤采集; 2）收获， 处理、储存、分类和分发高质量的脑组织和生物标本给UCI的ADRD研究人员 以及其他方面，与DMS和Biomarker Cores合作进行数据管理和生物标本 利用功能; 3）引入新的分析方法，使新的小胶质细胞研究UCI 研究人员在一个新的小胶质细胞生物学在AD的前沿; 4）纳入全载玻片成像（WSI）， 促进诊断、研究和教育，包括建立与加州大学WSI的接口 网络和UCI人工智能（AI）中心; 5）支持新的ADRD研究和推广， 与其他UCI ADRC核心和其他ADRC合作，包括涉及死后MRI的新研究， 透明脑组织的光片显微镜检查和WSI的AI研究;以及6）贡献独特的专业知识， 下一代AD临床医生和研究人员的教育和培训，包括Perez博士， 罗森达尔，神经病理学家和REC学员。