Core D-Neuropathology Core

核心 D-神经病理学核心

• 批准号: 10188384
• 负责人: EDWIN S MONUKI
• 金额: $ 43.18万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10188384
• 关键词: Adherence; Age; Aliquot; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease risk; Amyloid beta-Protein; Artificial Intelligence; Astrocytes; Autopsy; Award; Biological Markers; Biology; Blood specimen; Brain; California; Catalogs; Cells; Clinical; Clinical Data; Collaborations; Collection; Data Set; Deposition; Diagnosis; Diagnostic; Diagnostics Research; Disease; Doctor of Philosophy; Down Syndrome; Education; Education and Outreach; Ensure; Equipment and supply inventories; Faculty; Family; Fibroblasts; Functional disorder; Funding; Generations; Genetic Diseases; Glial Fibrillary Acidic Protein; Goals; Gold; Grant; Guidelines; Harvest; Head; Health system; Hour; Individual; Infrastructure; Institution; International; Light; Link; Longevity; Magnetic Resonance Imaging; Mentorship; Methods; Microglia; Microscopy; Minority; Morphology; Neurons; Outreach Research; Participant; Pathology; Performance; Practice Guidelines; Predisposition; Process; Protocols documentation; Publications; Reporting; Research; Research Personnel; Resources; Rotation; Sampling; Services; Site; Skin; Special Population; Stains; Standardization; Structure; System; Time; Training and Education; Universities; Visit; Work; adjudication; biobank; brain tissue; cell type; clinical trial participant; cohort; data management; diagnosis standard; digital; education research; genome wide association study; high risk; induced pluripotent stem cell; innovation; integration site; member; mixed dementia; neuropathology; next generation; novel; operation; outreach; professor; recruit; symposium; tau Proteins; whole slide imaging

PROJECT SUMMARY – NEUROPATHOLOGY CORE (CORE D) The UCI ADRC Neuropathology (NP) Core provides autopsy, diagnostic, and biorepository services for the three cohorts of the UCI ADRC - Uniform Data Set (UDS), 90+, and Down syndrome - which span a broad range of ages and susceptibilities to AD. The overarching goal of the NP Core is to support education, outreach, and research on AD and related disorders (ADRD) in collaboration with other ADRC cores and ADRD researchers to “identify, quantify, and validate factors that influence the risk of AD across the lifespan.” Since its inception, the NP Core has collected and maintained a considerable bank of high-quality biospecimens, which have been distributed broadly to NCRAD and federally-funded local, national, and international ADRD investigators and consortia. Core operations have been continually enhanced, and metrics of core performance are strong. To expand its capacity, three new faculty have joined the NP Core, including a neuropathologist who is also a REC mentee (Mari Perez-Rosendahl). Together with the other UCI ADRC Cores, the NP Core proposes six Aims to enhance its diagnostic, education, and research functions via collaboration, innovation, and education: 1) Provide accurate, timely, comprehensive, and standardized postmortem examinations and diagnostic reports on UDS subjects and special populations, including the addition of postmortem skin collection on selected cases in collaboration with the iPSC Core; 2) Harvest, process, store, catalog, and distribute high-quality brain tissue and biospecimens to ADRD researchers at UCI and beyond, collaborating with the DMS and Biomarker Cores in its data management and biospecimen utilization functions; 3) Incorporate new analysis methods to enable novel microglial studies by UCI investigators at the cutting-edge of a new microglial biology in AD; 4) Incorporate whole slide imaging (WSI) to facilitate diagnoses, research, and education, including the establishment of interfaces with a UC-wide WSI network and UCI artificial intelligence (AI) center; 5) Support novel ADRD research and outreach in collaboration with other UCI ADRC Cores and other ADRCs, including new studies involving postmortem MRI, light sheet microscopy of cleared brain tissues, and AI studies of WSIs; and 6) Contribute unique expertise to the education and training of the next generation of AD clinicians and researchers, including Dr. Perez- Rosendahl, neuropathologist and REC mentee.

项目摘要 – 神经病理学核心（核心 D） UCI ADRC 神经病理学 (NP) 核心为以下人群提供尸检、诊断和生物样本库服务： UCI ADRC 的三个队列 - 统一数据集 (UDS)、90+ 和唐氏综合症 - 涵盖广泛 年龄范围和 AD 易感性。 NP Core 的总体目标是支持教育、 与其他 ADRC 核心合作，开展 AD 及相关疾病 (ADRD) 的推广和研究 ADRD 研究人员“识别、量化和验证影响整个生命周期 AD 风险的因素”。 自成立以来，NP Core 收集并维护了大量的高质量 生物样本，已广泛分发给 NCRAD 和联邦资助的地方、国家和地区 国际 ADRD 调查人员和财团。核心业务不断增强，指标体系不断完善 核心性能强劲。为了扩大其能力，三名新教师加入了 NP 核心，其中包括一名 神经病理学家，同时也是 REC 学员 (Mari Perez-Rosendahl)。与其他 UCI ADRC 一起 Cores，NP 核心提出了六个目标，通过以下方式增强其诊断、教育和研究功能： 协作、创新、教育：1）提供准确、及时、全面、规范的 UDS受试者和特殊人群的尸检和诊断报告，包括 与 iPSC 核心合作，增加对选定病例的尸检皮肤采集； 2）收获， 处理、存储、编目并向 UCI 的 ADRD 研究人员分发高质量的脑组织和生物样本 以及其他方面，与 DMS 和 Biomarker Cores 在数据管理和生物样本方面进行合作 使用功能； 3) 结合新的分析方法，使 UCI 能够进行新颖的小胶质细胞研究 AD 小胶质细胞生物学前沿研究人员； 4) 将全玻片成像 (WSI) 纳入 促进诊断、研究和教育，包括与加州大学范围内的 WSI 建立接口 网络和UCI人工智能（AI）中心； 5) 支持新的 ADRD 研究和推广 与其他 UCI ADRC 核心和其他 ADRC 合作，包括涉及死后 MRI 的新研究， 透明脑组织的光片显微镜检查以及 WSI 的人工智能研究； 6) 贡献独特的专业知识 下一代 AD 临床医生和研究人员的教育和培训，包括 Perez 博士- Rosendahl，神经病理学家和 REC 学员。