INFLUENCE SUBSTRATE RIGIDITY ON MATURATION OF NEONATAL RAT VENTRICULAR MYOCYTES

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 心脏病的进展和心脏组织的发育伴随着细胞外基质机械性质的变化。例如，在缺血性和肥大性心脏病中，纤维化很常见。由于肌细胞的生长和重塑部分受机械信号的控制，因此收缩的机械阻力的差异可能反过来改变心肌细胞的行为。本研究旨在了解被动力学对心肌细胞功能的影响，并确定所涉及的信号传导机制，以确定新疗法的靶点。 Jacot JG，McCulloch AD & Omens JH.新生大鼠功能成熟的调控 按基质硬度列出的心肌细胞。在修订版中。 Jacot，JG，Omens，JH，McCulloch，AD. RhoA/ROCK信号通路在新生大鼠心肌细胞基质硬度调控中的作用在生物物理学会年会上的海报展示。2008年2月。 Jacot，JG，Wei，K，Omens，JH，McCulloch，AD，Mercola，M.人胚胎干细胞来源的心肌细胞收缩特性的功能表征。在生物工程学会第一届干细胞工程国际会议上的海报展示。2008年1月

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The progression of heart disease and the development of heart tissue are accompanied by changes in the mechanical properties of the extracellular matrix. For example, in ischemic and hypertrophic heart disease, fibrosis is common. Since myocyte growth and remodeling is in part governed by mechanical signaling, differences in the mechanical resistance to contraction may in turn alter cardiomyocyte behavior. This study aims to understand the effects of passive mechanics on cardiomyocyte function and to determine the signaling mechanisms involved in order to identify targets of novel therapies. Jacot JG, McCulloch AD & Omens JH. Control of the Functional Maturation of Neonatal Rat Cardiac Myocytes by Substrate Stiffness. In Revision. Jacot, JG, Omens, JH, McCulloch, AD. RhoA/ROCK Signaling in Substrate Stiffness Control of Noenatal Rat Cardiomyocyte Maturation. Poster presentation at the Biophysical Society annual meeting. February, 2008. Jacot, JG, Wei, K, Omens, JH, McCulloch, AD, Mercola, M. Functional characterization of contractile properties of human embryonic stem cell-derived cardiomyocytes. Poster presentation at the Society for Biological Engineering 1st International Conference on Stem Cell Engineering. January, 2008.