NEUROIMAGING STUDIES OF FRONTAL LOBE PATHOLOGY IN OCD

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 很少有磁共振（MR）的研究调查了可能的结构改变的前额叶皮层的个体与强迫症（OCD），尽管该地区的重要性，神经生物学模型的障碍。 额叶亚区在强迫症的评估是潜在的重要，因为它是已知的，额叶结构和功能的异质性。 在这项研究中，我们将使用皮质表面映射的方法来调查眶额叶皮质，这已经牵连到从功能性神经影像学研究的强迫症的病理生理。 25名符合DSM-IV诊断的强迫症患者和匹配的健康志愿者将接受MR成像扫描，包括124张连续T1加权冠状面SPGR MR图像（层厚= 1.5 mm）。据推测，与健康志愿者相比，患者将表现出眶额区灰质密度增加，这与功能性神经影像学研究一致，表明在休息条件和症状激发期间该区域代谢亢进。 灰质密度增加与反应抑制措施的神经心理功能恶化有关。 预计这些数据将产生重要的信息额叶皮质异常的神经生物学强迫症以及异常的结构功能关系的潜在作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Few magnetic resonance (MR) studies have investigated possible structural alterations of the prefrontal cortex in individuals with obsessive-compulsive disorder (OCD) despite the importance of this region to neurobiologic models of the disorder. Assessment of frontal subregions in OCD is potentially important because it is known that the frontal lobes are both structurally and functionally heterogeneous. In this study we will use methods for cortical surface mapping to investigate the orbital frontal cortex, which has been implicated in the pathophysiology of OCD from functional neuroimaging studies. Twenty-five patients with a DSM-IV diagnosis of OCD and matched healthy volunteers will receive MR imaging scans consisting of 124 contiguous T1-weighted coronal SPGR MR images (slice thickness = 1.5mm). It is hypothesized that compared to healthy volunteers, patients will demonstrate increased grey matter density in the orbital frontal region consistent with functional neuroimaging studies demonstrating hypermetabolism of this region during rest conditions and symptom provocation. Increased grey matter density will be associated with worse neuropsychological functioning on measures of response inhibition. It is expected that these data will yield important information regarding the potential role of frontal cortical abnormalities in the neurobiology of OCD as well as abnormal structure-function relations.