STRUCTURE DETERMINATION OF H/ACA PSEUDOURIDYLASE COMPLEX
STRUCTURE DETERMINATION OF H/ACA PSEUDOURIDYLASE COMPLEX
批准号:
7721258
负责人:
Hong Li
金额:
$0.35万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-05-15 至 2009-03-31
中文摘要
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
H/ACA假尿苷酶复合物负责核糖体、小核和转移RNA中尿苷核苷酸的位点特异性异构化。该复合物由至少三种蛋白质(Cbf5,Nop10和Gar1)和一种指导RNA组成。目前还没有这个复杂的结构。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
H/ACA pseudouridylase complex is responsible for site-specific isomerization of uridine nucleotides in ribosomal, small nuclear, and transfer RNAs. The complex is comprised of at least three proteins (Cbf5, Nop10, and Gar1), and a guide RNA. There is currently no structure of this complex.
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