Shared Resources-Cesium 137 Irradiator

S对公共卫生的研究。如果应用程序得到资助，则此 这一共享资源始于1991年，由治疗放射科提供资金。它 主要设备是J.L.Shepherd&lt制造的铯-137实验室辐照器(Mark I，型号68A)； 它包含两个铯-137源，每个源的活度分别为6000和100居里。 该仪器已被耶鲁大学医学院用股票&lt；提供的资金购买。 国立卫生研究院授予的仪器设备补助金(补助金编号1-S10-RR04813-01；普林西比 调查员，Ravinder Nath博士)。 铯-137辐照器共享资源(CISR)通过电离辐射提供对辐照的访问， 具体地说，是铯-137放射性衰变产生的662keV伽马射线。这个设施可以正常运转。 剂量范围为0.01cGymin~1500cGymin。铯-137辐射体的目的是提供一种 准确可靠的分子化合物、细胞培养、动物和人体肿瘤照射光源 细胞和整个动物实验。我们的具体目标是保持一台每天24小时、365小时可用的辐照器 任何需要伽马照射的临床或研究方案的天数/年。这家癌症中心的核心设施 为癌症中心的不同科学家提供了研究特定辐射诱导的影响的能力 细胞DNA的损伤，以及辐射损伤后涉及的修复途径等 放射生物学机制。所发射的辐射也可以作为癌症研究的工具来抑制 通过产生辐射诱导的骨髓嵌合小鼠在细胞培养或动物中的免疫反应。 在基于聚合物的三维剂量计的开发过程中，国际计算机科学研究院发挥了重要作用 在放射学中的应用，以及辐射物理和剂量学响应的研究 过热乳胶。在血液学实验室，细胞血液成分的伽马辐射仍然是 可接受的预防输血相关移植物抗宿主病的方法。本《公约》还可以 用于各种细胞、疫苗、药物制剂的灭菌。 自成立以来，《预防犯罪公约》已从38名首席调查员(76名青年会成员)提供了104名首席调查员 耶鲁大学各系/科室有能力进行各种癌症研究项目，包括辐射 大范围的剂量率。在过去的一年里，43名YCC成员，来自YCC研究项目的8个项目中的7个， 产生了总使用量的92%(同行评审的85%)。

s research to public health. If the application is funded, this This Shared Resource began in 1991, with funding provided by the Department of Therapeutic Radiology. It major equipment is a Cesium-137 laboratory irradiator (Mark I, Model 68A) manufactured by J.L. Shepherd an< Associates, Inc. It contains two cesium-137 sources with activities of 6,000 and 100 curies each. This instrument has been purchased by Yale University Medical School with funds provided by a Share< Instrumentation Grant from the National Institutes of Health (grant number 1-S10-RR04813-01; Principe Investigator, Dr. Ravinder Nath). The Cesium-137 Irradiator Shared Resource (CISR) provides access to irradiations by ionizing radiation, specifically 662 keV gamma rays from the radioactive decay of cesium-137. This facility can operate at dose rates ranging from 0.01 cGy/min to 1500 cGy/min. The purpose of the Cesium-137 Irradiator is to provide an accurate and reliable irradiation resource for molecular compounds, cell culture, animal and human tumor cells, and whole animal experiments. Our specific aim is to keep an irradiator available 24 hrs/day, 365 days/year for any clinical or research protocol that requires gamma irradiation. This cancer-center core facility provides various scientists in the Cancer Center the ability to study the effects of specific radiation-induced lesions in the DNA of cells, as well as what repair pathways are involved after radiation damage, and other radiobiological mechanisms. The radiation delivered also can be used as a tool in cancer research to suppress the immune response in cell cultures or animals by generating irradiation-induced bone marrow chimeric mice. The CISR has been instrumental in the development of 3-dimensional polymer based dosimeters for applications in radiology, as well as the investigations of the radiation physics and the dosimetric response of superheated emulsion gels. In hematology labs, gamma irradiation of cellular blood components is still the acceptable method for the prevention of transfusion-associated graft-versus-host disease. This CISR can also be used for the sterilization of various cell, vaccine and drug preparations. Since its inception, the CISR has enabled 104 principal investigators (76 YCC Members) from 38 departments/sections at Yale the ability to perform various cancer research projects involving irradiations over a wide range of dose rates. In the past year, 43 YCC members, from 7 out 8 of the YCC Research Programs, generated 92% of the total usage (85% peer-reviewed) of the CISR.