Personal Ozone Monitor

描述（申请人提供）：在本提案中，我们响应了美国国家环境健康科学研究所（NIEHS）在PHS 2009-2综合征求，暴露生物学计划，第1节，为“新产品/设备，工具，分析，以提高我们的能力，精确测量环境暴露的个人与高时间和空间分辨率。“根据招标，该设备应具有适当的规模，可现场部署和/或可穿戴。光化学空气污染中形成的臭氧对人类健康的不利影响已得到充分证明，包括肺功能下降和哮喘等原有呼吸道疾病恶化。在臭氧浓度高的情况下，急诊室就诊人数、每日住院人数和死亡率都会增加。个人臭氧监测仪（POM）是需要对臭氧的生理影响进行环境健康研究，并验证人体暴露的计算机模型。在第一阶段的项目中，我们成功地开发了一个小（4 x 3 x 1.5英寸），重量轻（0.7磅），低功耗（2.9瓦），低成本（795美元的零件），电池供电的POM的基础上建立了良好的紫外线吸收的方法（EPA联邦参考方法）。口袋大小的POM具有#2 ppb的精度和准确度，每10秒进行一次新的测量，并具有用于将数据下载到个人计算机的内部数据记录器。在此处提议的第二阶段项目期间，我们将进一步改进和完成POM的开发，以包括以下内容：1）印刷电路板上的专用接地层，以进一步降低噪声，2）坚固耐用、易于制造的外壳，3）由液晶显示器和键盘组成的人机界面，4）具有电池充电器的对接坞，5）用于与地理坐标共定位测量的GPS，以及6）POM与对接站之间的无线通信。将开发支持新功能的固件，并将开发用于计算机数据采集和绘图以及将臭氧数据上传到网络的软件。POM的有效性和准确性将在新泽西医学和牙科大学环境和职业健康科学研究所（EOHSI）进行的个人暴露监测研究中进行评价。除了个人臭氧监测之外，还确定了几个大型的袖珍臭氧监测器市场;其中包括迅速增长的臭氧工业应用和全球臭氧项目（GO 3），这是一个国际教育项目，高中生在该项目中建立和操作臭氧监测站，并在谷歌地球地图上共享其数据。 公共卫生相关性：将完成并评价袖珍电池供电的个人臭氧监测器（POM）的开发，作为测量个人在正常日常活动中时间分辨暴露的一种手段。POM将促进对空气污染中形成的臭氧对人类健康的不利影响的生理学研究。

DESCRIPTION (provided by applicant): In this proposal we respond to the call by the National Institute of Environmental Health Sciences (NIEHS) in the PHS 2009-2 Omnibus Solicitation, Exposure Biology Program, Section 1, Technologies for Generating Precise Measures of Environmental Exposures for "new products/devices, tools, assays to improve our ability to precisely measure environmental exposures to individuals with high temporal and spatial resolution." According to the solicitation, the device should be of appropriate scale to be field deployable and/or wearable. Ozone, formed in photochemical air pollution, has well documented adverse effects on human health, including reduction of lung function and aggravation of preexisting respiratory disease such as asthma. Emergency department visits, daily hospital admissions and mortality increase during episodes of high ozone concentration. A Personal Ozone Monitor (POM) is required for environmental health studies of the physiological effects of ozone and for validating computer models of human exposure. In the Phase I project we successfully developed a small (4 x 3 x 1.5 inch), light weight (0.7 lb), low power (2.9 watts), low cost ($795 in parts), battery-operated POM based on the well established method of UV absorbance (an EPA Federal Reference Method). The pocket-sized POM has a precision and accuracy of # 2 ppb, makes new measurements every 10 s and has an internal data logger for downloading data to a personal computer. During the Phase II project proposed here, we will further improve and finalize the development of the POM to include the following: 1) dedicated ground plane on the printed circuit board to further reduce noise, 2) ruggedized, easily manufactured enclosure, 3) human interface consisting of liquid crystal display and keypad, 4) docking station with battery charger, 5) GPS for co-locating measurements with geographical coordinates, and 6) wireless communication between the POM and docking station. Firmware will be developed to support the new functions, and software will be developed for data acquisition and graphing by a computer and for uploading ozone data to the web. The efficacy and accuracy of the POM will be evaluated in personal exposure monitoring studies conducted at the Environmental and Occupational Health Sciences Institute (EOHSI) of the University of Medicine and Dentistry of New Jersey. Several large markets for a pocket-sized ozone monitor have been identified in addition to personal ozone monitoring; these include rapidly growing industrial applications of ozone and the Global Ozone (GO3) Project, an international educational project in which high school students build and operate an ozone monitoring station and share their data as an overlay on the Google Earth" map. PUBLIC HEALTH RELEVANCE: Development of a pocket-sized, battery powered Personal Ozone Monitor (POM) will be completed and evaluated as a means of measuring the time-resolved exposure of individuals during normal daily activities. The POM will facilitate physiological studies of the adverse effects of ozone, formed in air pollution, on human health.