CH/BIDMC/Harvard Medical School Neurology Resident Research Education Program

描述（由申请人提供）：该奖项的目的是为贝斯以色列女执事医疗中心（BIDMC）和波士顿儿童医院（CHB）神经内科住院医师培训项目的选定住院医师创造一个机会，在住院医师的第三年和随后的奖学金年里，参加9到24个月的强化、指导和研究教育体验。该培训旨在帮助参与的住院医生为独立指导研究奖的成功竞争做好准备，并促进从住院医生/研究员到临床医生-科学家的过渡。每位参与者将与来自CHB、BIDMC和哈佛医学院（HMS）的37位导师中的一位一起工作。它们都有NIH的积极资助和培养临床科学家的历史。建议的导师涵盖临床和基础神经科学的所有主要领域，其中包括来自CHB的20名研究员，来自BIDMC的16名研究员，以及来自HMS的1名研究员（Michael Greenberg博士，CHB神经生物学项目前负责人，现任HMS神经生物学主席）。其中17人从事临床/转化神经科学研究，12人从事基础神经科学研究，8人同时从事基础和临床/转化研究。导师不仅来自神经病学/神经生物学，还来自CHB神经病理学、CHB神经放射学、CHB神经外科、BIDMC神经病理学和BIDMC麻醉科疼痛研究项目。选定的常驻参与者将学习最先进的实验室技能，并将获得进行负责任的研究所必需的关键专业知识。收集和分析的数据将用于出版物以及未来的NIH提案。该计划将由指导委员会管理，该指导委员会由PD/ pi，部门主席和参与住院医师计划的住院医师主任组成。该委员会将共同努力征聘和选择受训人员，监测他们的进展，并评价培训经验的有效性。

DESCRIPTION (provided by applicant): The aim of this award is to create an opportunity for selected residents in the neurology residency training programs of the Beth Israel Deaconess Medical Center (BIDMC) and the Children's Hospital Boston (CHB) to participate for 9 to 24 months in an intensive, mentored, research educational experience during the third year of residency and subsequent fellowship years. This training will be designed to prepare participating residents for successful competition for independent mentored research awards, and will facilitate the transition from resident/fellow to clinician-scientist. Each participant will work with one of 37 mentors, who have been recruited from the faculties of CHB, BIDMC, and Harvard Medical School (HMS). All have active NIH funding and a history of training clinician-scientists. The proposed mentors cover all major areas of the clinical and basic neurosciences, and include 20 investigators from CHB, 16 investigators from BIDMC, and one investigator from HMS (Dr. Michael Greenberg, former leader of the Neurobiology Program at CHB, now Chair of Neurobiology at HMS). Seventeen of these investigators are engaged in clinical/translational neuroscience research, twelve conduct basic neuroscience research, and eight are involved in both basic and clinical/translational research. Mentors have been drawn not only from the Departments of Neurology/Neurobiology, but also from the CHB Division of Neuropathology, the CHB Division of Neuroradiology, the CHB Department of Neurosurgery, the BIDMC Division of Neuropathology, and the Pain Research Program of the BIDMC Department of Anesthesia. Selected resident participants will learn state-of- the-art laboratory skills and will acquire the critical expertise necessary for the conduct of responsible research. Data collected and analyzed will serve for publications as well as for future NIH proposals. The program will be governed by a Steering Committee consisting of the PD/PIs, the Department Chairs, and the Residency Directors of the participating residency programs. This Committee will work together to recruit and select trainees, to monitor their progress, and to evaluate the effectiveness of the training experience. PUBLIC HEALTH RELEVANCE: Illnesses affecting the nervous system remain a great challenge to medical research. The discovery of the causes of these illnesses, leading to earlier diagnosis and better treatments, requires research that relies increasingly on conceptual complexities and sophisticated methodologies. The present R25 proposal is aimed at developing researchers that can combine the clinical expertise obtained during residency with a well developed and focused investigative research program. Neurology residents are keenly aware of the problems that need to be solved and are especially motivated and energized to solve them. The CHB/BIDMC residency program combines both adult and child neurology within an environment that has great depth in basic and clinical neuroscience. Mentors chosen for the R25 include leading NIH funded basic cellular and molecular neuroscientists, as well as successful physician scientists actively engaged in clinical and basic neuroscience and experienced in, and eager to train physician scientists. The main focus of the proposed program will be to prepare physicians for independent and competitive research.