Center Driven Research

JHICC中心主导研究的愿景是执行对ION有直接影响的项目 渠道探索的发展，并为其他中心的研究活动提供高价值。这将极大地 使整个NIH-分子图书馆计划(MLP)受益。在这里，我们提出两个项目。第一个项目 专注于技术开发。具体地说，我们建议开发基于细胞的无标记检测 离子通道和受体活性。第二个项目侧重于通过以下方式实现综合服务功能 为预测复合心脏毒性提供高水平的技术评估。这两个项目需要 利用我们自己的专业知识，并应立即为我们自己的努力和整体 美国国立卫生研究院网络中心计划。 1.基于细胞的离子通道和受体活性的无标记检测。 2.心脏毒性筛查以评价化合物

The vision of JHICC center-driven research is to perform projects that have an immediate impact on ion channel probe development and offer high value for the research activities of other Centers. This will greatly benefit the overall NIH-Molecular Library Programs (MLP). Here we propose two projects. The first project focuses on technology development. Specifically, we propose to develop cell-based label-free detection of ion channel and receptor activities. The second project focuses on a comprehensive service function by providing a high-level technical evaluation to predict compound cardiotoxicity. These two projects take advantage of our own expertise and should provide immediate benefit to both our own effort and the overall program of NIH network centers. 1. Cell-based label-free detection of ion channel and receptor activitiesrs. 2. Cardiac toxicity screen to evaluate compounds