Extending and enhancing an fMRI power analysis tool.

描述(申请人提供)：这项拟议的研究旨在开发一种强大、灵活的功率计算工具，用于计划团体功能磁共振成像(FMRI)研究。这将需要扩展FMRIPower的当前版本，这是一种正在开发的软件工具，目前列在NITRC数据库中。功率计算需要来自先前分析的结果，但灵活的功率分析模型提高了找到能够以最低成本执行的强大研究设计的能力。当前版本的FMRIPower只允许来自FMRIB软件库(FSL)的输入，并且只允许用户更改研究中的受试者数量。通过结合我们以前开发的方法，我们将使FMRIPower可供更多不同的软件包使用，包括统计参数映射(SPM)和功能神经图像分析(AFNI)软件包，我们将扩展POWER模型，以允许受试者数量以及每个受试者的跑步次数和每次跑步发生的刺激事件数量的波动。NITRC网站将有助于分发和评估FMRIPower。所产生的工具将是规划未来功能磁共振研究的一项资产，将导致更好、更具成本效益地利用研究资金，因为功率分析有助于确保收集到适当的样本量。公共卫生相关性：拟议的研究旨在通过提供手段来改善公共健康，方法是在小组功能磁共振成像中进行灵活的功率计算，以计划具有足够高功率的研究设计，如果存在效果，则在保持在拟议预算的情况下检测效果。目前缺乏灵活的软件来计算群体功能磁共振研究的功率，这经常导致研究人员放弃功率计算，或者根据不相关研究的功率建立样本大小，导致研究能力太弱而无法检测效果或昂贵的超负荷研究。我们免费提供的软件工具的开发将允许许多不同fMRI软件包的用户进行功率分析，并能够对研究设计进行许多调整，以最大限度地提高功率和最大限度地降低成本。

DESCRIPTION (provided by applicant): The proposed research aims to develop a powerful, flexible power calculation tool to be used for planning group functional magnetic resonance imaging (FMRI) studies. This will require extending the current version of FMRIPower, a software tool under development that is currently listed in the NITRC database. A power calculation requires results from a previous analysis, but flexible models for power analysis increase the ability to find a powerful study design that can be carried out for the lowest cost. The current version of FMRIPower only allows input from the FMRIB Software Library (FSL) and only allows users to alter the number of subjects in the study. By incorporating methods that we have previously developed, we will make FMRIPower accessible to a wider variety of software packages, including the Statistical Parametric Mapping (SPM) and Analysis of Functional NeuroImages (AFNI) packages, and we will extend the power model to allow fluctuations in the number of subjects as well as the number of runs per subject and the number of stimulus events that occur per run. The NITRC website will be helpful in distributing and assessing FMRIPower. The resulting tool will be an asset for the planning of future fMRI studies that will result in better and more cost- effective utilization of research funds, since power analyses help insure the appropriate sample size is collected. PUBLIC HEALTH RELEVANCE: The proposed research aims to improve public health by supplying the means to carry out a flexible power calculation in group fMRI to plan study designs with high enough power to detect an effect, if it is present, while staying within the proposed budget. The current lack of flexible software for calculating power for group fMRI studies often leads investigators to forego power calculation or base sample sizes on power from unrelated studies, leading to studies that are too underpowered to detect an effect or costly overpowered studies. The development of our freely available software tool will allow users of many different fMRI software packages to carry out power analyses with capabilities to make many adjustments to the study design in order to maximize power and minimize cost.