Comparison of kidney function measurement methods in the community

描述（由申请人提供）： 项目概要：候选人是一名肾病学家，于2006年7月1日在马约诊所开始工作。在过去的4年中，作为一名肾脏病学实习生，候选人获得了临床研究硕士学位，首次撰写了10篇同行评审文章，并获得了机构（T32）和个人（F32）国家研究奖。他在慢性肾脏疾病流行病学和肾功能方法方面的专业知识获得了全国的关注。他是疾病控制和预防中心的资助评审员，并将主持美国肾脏病学会肾脏周（2006年）的研讨会。 环境将包括马约诊所-罗切斯特，在那里他将有一个肾脏病学和流行病学的联合任命。他的担保人斯蒂芬·特纳医学博士医学教授，将为他提供访问数据的机会，并培训他成为一名独立的调查员。他的导师团队还将包括两名流行病学教授，一名生物统计学副教授和肾功能实验室的联合主任，该实验室每年进行5500次“金标准”肾功能测量。 该项目将比较金标准方法（碘酞酸清除率）和更方便但可能不太准确的方法（用于临床实践和大多数研究中的血清肌酐、胱抑素C、估计方程和肌酐清除率）之间的肾功能测量。该项目的独特之处在于在社区样本（导师队列和候选人队列）中比较这些肾功能方法。将确定肾功能测量方法对冠状动脉钙化的影响以及与慢性肾脏疾病相关的风险因素。 发布：在美国，800万成年人有中度至重度肾功能下降，并面临昂贵的病态干预（透析或移植）和心血管疾病的风险。需要验证肾功能方法，以在早期阶段识别慢性肾脏疾病，表征其危险因素，并开发新的治疗策略。

DESCRIPTION (provided by applicant): Project Summary: The candidate is a nephrologist starting a staff position at the Mayo Clinic on July 1st, 2006. During the past 4 years as a nephrology trainee, the candidate obtained a Master's degree in Clinical Research, first-authored 10 peer-reviewed articles, and received institutional (T32) and individual (F32) National Research Awards. His expertise in the epidemiology of chronic kidney disease and in kidney function methods has gained national attention. He was a grant reviewer for the Centers for Disease Control and Prevention and will moderate a symposium at the American Society of Nephrology Renal Week (2006). The environment will consist of Mayo Clinic - Rochester, where he will have a joint appointment in Nephrology and Epidemiology. His sponsor, Stephen Turner, M.D., Professor of Medicine, will provide him with access to data and train him to be an independent investigator. His mentorship team will also include two Professors of Epidemiology, an Associate Professor of Biostatistics, and the Co-director of the Renal Function Laboratory where 5500 'gold-standard' kidney function measurements are performed annually. The project will compare kidney function measurements between a gold standard method (iothalamate clearance) and more convenient, but potentially less accurate methods, used in clinical practice and in most studies (serum creatinine, cystatin C, estimating equations, and creatinine clearance). The unique feature of this project will be to compare these kidney function methods in community-based samples (mentor's cohort and candidate's cohort). The effect of the kidney function measurement method on coronary artery calcification and risk factor associations with chronic kidney disease will be determined. Relevence: In the United States, 8 million adults have moderate-to-severe reductions in kidney function and are at risk for costly morbid interventions (dialysis or transplantation) and cardiovascular disease. Validation of kidney function methods is needed to identify chronic kidney disease at an earlier stage, characterize its risk factors, and develop new treatment strategies.