Training in Translational Science and Cardiovascular Medicine

描述（由申请人提供）：本修订提案为心血管疾病转化研究的新培训项目寻求资金。该项目将通过俄勒冈健康与科学大学心血管医学部和心脏研究中心招收博士和医学博士实习生。6名博士后将获得为期两年的研究培训资金。该项目将提供令人兴奋的机会，在五个已建立的小组之一进行从实验室到床边的培训，这些小组专门研究1)成人疾病的早期起源，2)肥胖/糖尿病，3)细胞信号，4)生理系统，以及5)人类研究。34名教师都是备受认可和资助的科学家，他们在培养博士后方面有着良好的记录。专业培训将包括分子成像、小鼠遗传模型、肥胖和心血管疾病的灵长类动物模型、临床MRI研究、机械力-基因表达联系、心血管失调的数学模型。实验室研究将辅以课程作业、研讨会、期刊俱乐部和特定科学小组的会议。这个项目在OHSU的独特之处在于，指导将以团队的方式进行。一名基础科学家和一名临床科学家加上一名额外的科学家将在每个实习生的指导委员会中任职。培训的结果将是具有广阔视野和专注于将科学造福于患者的科学家。该应用程序包括针对服务不足的少数族裔学员的强大招聘计划和评估程序。一个强大的项目咨询委员会将监督每个学员的进展，因为他们达到了为研究事业做准备的特定里程碑。这些从这个项目毕业的科学家将准备调查主要的公共卫生问题，包括日益增加的中风、糖尿病、冠心病、心力衰竭和肥胖的全球负担。

DESCRIPTION (provided by applicant): This revised proposal seeks funds for a new training program in translational research applied to cardiovascular disease. The program will recruit PhD and MD trainees through the Division of Cardiovascular Medicine at the Oregon Health & Science University and the Heart Research Center. Six post-doctoral fellows will be offered funding for two years of research training. The program will offer exciting opportunities for bench to bedside training in one of five established groups that specialize in 1) the early origins of adult disease, 2) obesity/diabetes, 3) cell signaling, 4) physiological systems, and 5) human research. The 34 faculty are highly recognized and funded scientists who have a track record of training postdoctoral fellows. Specialty training will include molecular imaging, mouse genetic models, primate models of obesity and cardiovascular disease, clinical MRI research, mechanical forces-gene expression links, mathematical models of cardiovascular dysregulation. Laboratory research will be supplemented by course work, seminars, journal club, and meetings within a specific science group. This program is unique at OHSU in that mentoring will be carried out in a team approach. A basic scientist and a clinical scientist plus one additional scientist will serve on each trainee's mentoring committee. The training outcome will be scientists with a broad outlook and a focus on bringing science to the benefit of patients. The application includes a strong recruitment program for underserved minority trainees and an evaluation process. A strong Program Advisory Committee will monitor the progress of every trainee as they meet specific mileposts in preparation for a research career. These scientists that graduate from this program will be prepared to investigate major public health issues including the increasing global burden of stroke, diabetes, coronary heart disease, heart failure and obesity.