Biostatistics Core

本计划项目的生物统计和数据管理(BDM)核心将为 费用设计、数据管理、数据分析和数学建模 项目。我们还将协助起草数据分析报告，并为所有建议的 探险和研究。具体目标包括：1)支持研究设计，执行数据分析，准备 分析报告，并协助起草摘要和手稿，以便出版与本研究有关的所有研究 计划项目；2)支持包含Flow的多参数流式细胞仪数据分析 细胞术数据门控以识别亚群，CFSE标记数据建模/分析以量化细胞 3)提供数学建模和统计分析服务 体内氚标记实验测定体内细胞增殖和动力学的关键参数 人体受试者；4)为所提议的项目执行高通量微阵列数据分析；以及5) 为所有项目和研究提供集中的数据管理服务。为了实现这些目标， BDM核心，我们组建了一支由生物统计学家、生物数学家组成的经验丰富的团队 在所有所需服务方面拥有各种专业知识的建模师和数据经理。BDM核心成员 将在实验设计、数据分析和准备方面与项目调查人员密切合作 分析报告和稿件。

Biostatistics and Data Management (BDM) Core of this program project will provide support and services for expenmental design, data management, data analysis and mathematical modeling for each of the proposed projects. We will also assist in drafting data analysis reports and preparing manuscripts for all proposed expehments and studies. Specific aims include: 1) Support study design, perform data analysis, prepare analysis reports, and assist in drafting abstracts and manuscripts for publication related to all studies in this program project; 2) Provide support for multi-parameter flow cytometry data analyses that include flow cytometry data gating to identify sub-populations and CFSE labeling data modeling/analysis to quantify cell proliferations; 3) Provide services of mathematical modeling and statistical analysis for the proposed deuterium in vivo labeling expehments to determine key parameters of cell proliferation and kinetics in vivo in human subjects; 4) Perform analysis of high throughput microarray data for the proposed projects; and 5) Provide centralized data management services to all projects and studies. In order to achieve these aims of the BDM Core, we have formed an experienced team consisting of biostatisticians, biomathematical modelers, and data managers with a variety of expertise in all required services. The BDM Core members will closely work with the project investigators in design of experiments, data analysis and preparation of analysis report and manuschpts.