Formative Center for the Evaluation of Environmental Impacts on Fetal Development

描述(由申请人提供)：行政核心的主要目标是促进、组织和促进形成中心的跨学科研究和核心活动。项目主任/首席调查员将以最大限度地利用团队的才华和技能的方式提供领导、监督和组织控制，以实现四个项目目标：1)在基础和临床研究方面提供领导和创新，以促进我们对环境应激源及其对胎儿发育的影响的了解；2)扩展跨学科研究，拓宽我们对与发育暴露相关的健康风险和与疾病相关的潜在分子机制的理解；3)建立跨领域的桥梁并创造新的跨学科研究、培训和指导机会；以及4)有效地传达潜在的健康危害并将基础研究成果转化为公共健康的利益。行政核心将作为该计划的枢纽，通过发展组织结构并建立在形成中心成员之间、与临床医生之间、与研究人员之间、与公众之间、与NIEHS工作人员之间以及与其他儿童环境健康中心和形成中心之间的沟通机制。负责任的财政和资源管理将是首席调查员的主要责任，项目经理将提供协助。行政核心将追求以下具体目标： 具体目标1：提供、支持和发展维持和适应跨学科基础和应用研究和培训增长的进程。 具体目标2：维持一种加强团队建设和促进信息传播的沟通结构。 具体目标3：实施以最佳方式促进方案目标并确保最佳和最负责任地使用现有资源的机制。 公共卫生相关性：这个形成中心的总体目标是开发新的生物标记物，用于环境暴露的不利影响，这些环境暴露影响胎儿发育并产生儿童和成人疾病。利用跨学科的方法，将设计研究、教育和培训干预措施，以解决孕妇、家庭和社区对环境化学品及其发育中儿童健康的担忧。

Description (provided by applicant): The primary objective of the Administrative Core is to promote, organize and facilitate the interdisciplinary research and core activities of the Formative Center. The Program Director/Principal Investigator will provide leadership, supervision and organizational control in a manner that best utilizes the team's talents and skills towards four programmatic objectives: 1) provide leadership and innovation in basic and clinical research that furthers our understanding of environmental stressors and their impact on fetal development, 2) expand interdisciplinary research that broadens our understanding of the health risks associated with developmental exposures and the underlying molecular mechanisms associated with disease, 3) build bridges across fields and create new interdisciplinary research, training, and mentoring opportunities, and 4) effectively communicate the potential health hazards and translate the basic research findings for the benefit of public health. The Administrative Core will function as the hub of the program by developing the organizational structure and creating mechanisms for communication among the members of the Formative Center, with clinicians, with researchers, with the public, with NIEHS staff, and with other Children's Environmental Health Centers and Formative Centers. Responsible fiscal and resource management will be the primary responsibility of the Principal Investigator, aided by the Program Manager. The Administrative Core will pursue these Specific Aims: Specific Aim 1: Provide, support and develop processes that sustain and accommodate the growth of interdisciplinary basic and applied research and training. Specific Aim 2: Maintain a communication structure that strengthens team building and facilitates the dissemination of information. Specific Aim 3: Implement mechanisms that will optimally promote the program's objectives and ensure the best and most responsible use of the available resources. Public Health Relevance: The over-arching goal of this Formative Center is to develop novel biomarkers for the adverse effects of environmental exposures that impact fetal development and produce childhood and adult disease. Using an interdisciplinary approach, research, educational, and training interventions will be designed to address the concerns that pregnant women, families, and communities have about environmental chemicals and the health of their developing children.