CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 俄勒冈州的生物医学研究机构是杰出的，并为临床/转化性研究的重大扩展做好了准备。我们建议成立俄勒冈州临床和翻译科学研究所(OCTSI)。OCTSI将从根本上改变生物医学研究，为 临床/转译研究。它将利用现有的优势，消除阻碍研究速度和增长的障碍。OCTSI的核心是俄勒冈健康与科学大学(OHSU)和Kaiser Permanente的健康研究中心(KPCHR)之间的牢固合作伙伴关系，该中心汇集了 强大的生物医学研究型大学和以实践为基础的创新研究中心，与庞大的患者群体相关。这一合作为人类研究领域的扩展提供了独特的机会，并为人类健康的重大进展奠定了基础。俄勒冈州临床和转克隆研究的转变通过以下方面得到加强：+对OCTSI的强有力的机构支持，表现为重大的行政改革以及大量财政和空间资源的承诺+OHSU和KPCHR的学术人员完全支持OCTSI倡议和制定 强大的多学科OCTSI领导团队+整合资源以形成临床/转化性研究的协调基础设施+与社区的紧密联系以及该地区对人类研究议程的参与 我们确定了OCTSI的三大目标，并提出了影响深远、明确可行的实现这些目标的方法。我们将1)建立一个专门致力于临床/转化性研究学科的学术之家(OCTSI)，2)培养一支训练有素的跨学科新干部队伍 研究人员通过强大、多样化的教育课程，3)创建“研究共享空间”--一个协调的核心研究工具基础设施，极大地扩大研究机会，并为他们提供统一、有效的获取途径。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. Biomedical research institutions in Oregon are outstanding, and are prepared for a major expansion in clinical/translational investigation. We propose to form the Oregon Clinical and Translational Science Institute (OCTSI). The OCTSI will fundamentally change biomedical research to create a vibrant academic home for clinical/translational investigation. It will leverage existing strengths and remove barriers to the pace and growth of research. At the heart of the OCTSI is a robust partnership between Oregon Health & Science University (OHSU) and Kaiser Permanente's Center for Health Research (KPCHR) that brings together a strong biomedical research university and an innovative practice-based research center associated with a large patient population. The collaboration provides unique opportunities for expansion across the spectrum of human investigation, and sets the stage for major advances in human health. Transformation of clinical and translatlonal research in Oregon is enhanced by: + Robust institutional support for the OCTSI, manifest by significant administrative change as well as the commitment of substantial financial and space resources + Academic faculties at OHSU and KPCHR that fully support the OCTSI initiative and the development of a strong, multidisciplinary OCTSI leadership team + Merging of resources to form a coordinated infrastructure for clinical/translational research + Strong ties to the community and the involvement of the region in the human research agenda We have identified three major goals for the OCTSI, and propose far-reaching, explicit and feasible approaches to achieve them. We will 1) Create an academic home (the OCTSI) specifically devoted to the discipline of clinical/translational research, 2) Nurture a new cadre of highly-trained, interdisciplinary investigators through a strong, diverse educational curriculum, 3) Create a "Research Commons" - a coordinated infrastructure of core research tools that greatly expands research opportunities and provides a unified, effective means for their access.