Identifying the critical components of growth factor-mediated survival pathways

细胞寿命(细胞存活)的调节由生长因子控制，是所有生物过程的核心。然而，人们对细胞内开启或关闭存活的分子开关知之甚少。我们建议识别和描述细胞内控制细胞生存和死亡之间平衡的分子开关。针对这些开关的特定成分，可能会为癌症和传染病的治疗提供新的方法。

The regulation of cell lifespan (cell survival) is controlled by growth factors and lies at the heart of all biological processes. However, little is known of the molecular switches inside cells that either turn survival on or off. We propose to identify and characterize the molecular switches inside cells that control the balance between cell survival and death. Targeting specific components of these switches may provide new approaches for the treatment of cancer and infectious diseases.