SPATIAL LEARNING - PILOT STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 妇女是艾滋病毒感染人数增长最快的群体，占所有成年艾滋病毒感染者的四分之一。 加勒比地区的艾滋病。大多数关于艾滋病毒相关神经认知障碍（HAND）的研究都是 关于什么类型的学习受到影响或学习是否受到影响的问题存在冲突。使用 翻译空间学习和记忆范式在人类和动物模型中的评估 这可能有助于进一步了解手。动物模型的研究表明， 与HIV感染相关的水迷宫任务的空间学习和记忆。在 目前，我们可以使用人类版本的水迷宫将这些发现翻译给人类。 名为“记忆岛”（MI），它使用虚拟现实导航和对象 该识别称为“新颖图像/新颖位置”（NINL），其使用图片识别。 这些部分学习和记忆任务似乎对性别/性别的影响敏感， 成人认知障碍（apoE）的遗传风险因素及其与表现的相关性 在相应的小鼠模型中。我们的目标是弥合认知功能与认知功能之间的差距。 通过使用MI和NINL试验以及沿着 传统的测试，以评估载脂蛋白E基因型之间的相互作用，HIV感染， 女性的认知。我们提出了一个横断面研究的妇女，20艾滋病毒血清阳性， 20个对照以确定：1）管理空间学习和记忆测试的可行性， 2)艾滋病毒感染对空间学习和记忆测试表现的影响，3） 如果空间学习和记忆测试与HAND相关联，4）如果空间学习 和记忆力测试与患者的病毒免疫特征相关，并探索5） apoE基因对空间学习记忆成绩的影响。这项研究意义重大 通过将啮齿动物模型，关于空间学习和记忆， 感染了艾滋病毒

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Women are the fastest growing group with HIV infection making up ¿ of all adults living with HIV in the Caribbean. Most studies on HIV-associated Neurocognitive Disorders (HAND) are conflicting on what type of learning is affected or if learning is affected at all. Using a translational spatial learning and memory paradigm assessed in humans and animal models may aid in the further understanding of HAND. Studies in animal models show impairments associated with HIV infection in the water maze task of spatial learning and memory. At present we can translate these findings to humans using a human version of the water maze entitled "Memory Island" (MI), which uses virtually reality navigation and the object recognition entitled "Novel Image/Novel location" (NINL), which uses picture recognition. These partial learning and memory task appear to be sensitive to effects of sex/gender and genetic risk factors for cognitive impairments (apoE) in adults and correlates to performance in corresponding mouse models. Our goal is to bridge the gap between cognitive function in HIV-seropositive women and animal models by using the MI and NINL tests along with conventional testing to assess interactions between apoE genotype, HIV infection, and cognition in women. We propose a cross sectional study of women, 20 HIV-seropositive and 20 controls to determine: 1) the feasibility to administer spatial learning and memory tests, 2) the effect of HIV infection in the performance of the spatial learning and memory tests, 3) if the spatial learning and memory test are associated with HAND, 4) if the spatial learning and memory tests correlate with patient's viral-immune profile, and to explore 5) if the role of apoE gene on the performance of spatial learning and memory test. This study is significant by translating an animal rodent model, regarding spatial learning and memory, to humans with HIV.