Building Biomedical Research Center at VSU

描述（由申请人提供）：NCMHD-RIMI计划的目的是通过向准备大量少数民族学生和生物医学教师的机构提供资源来减少健康差距。基于这些目标，弗吉尼亚州立大学（VSU）提出了一个RIMI计划，旨在扩大和加强基础设施和能力的VSU进行基础生物医学研究，这将解决并最终消除健康差距。该计划将开发基础设施，以加强VSU的研究，为学生和教师注入创新的教育经验，使教师和学生接触尖端的生物医学研究，并通过合作加强少数民族教师/学生参与生物医学研究。 VSU-RIMI计划的目标是：一）建立在VSU的生物医学研究的研究能力，二）促进教师和学生在生物医学和行为研究的参与，以及iii）加强在生物医学科学和健康差距的学术课程。VSU-RIMI计划提出了四个主要核心：行政核心，共享资源/基础设施核心，教师发展研究核心和学术增强核心。这四个核心与拟议的具体目标包括所有主要目标，这是NCMHD-RIMI计划的目标。在教师的研究核心，我们提出了三个研究项目，处理健康差距和人类健康问题。这些次级项目是：1）寻找遗传性人类疾病-糖尿病易感性组分的比较基因组学策略，2）早老素突变和淀粉样蛋白在阿尔茨海默病发展中的相互作用的研究，和3）宿主易感性或抗性和对内部寄生虫感染的免疫应答的比较和功能基因组学方法。 我们提议的RIMI计划将包括一个由项目主任布朗博士领导的人员团队，一名计划协调员，一名研究助理和三名担任共同PI的教员。管理团队将由一个机构咨询委员会提供咨询，整个RIMI计划将由一个外部咨询委员会监督。该计划包括弗吉尼亚大学，路易斯安那州立大学，犹他州州立大学，威廉和玛丽学院作为合作机构，这是研究密集型机构。RIMI计划将每年由外部顾问进行评估，并将评估拟议和实际成就，并向外部咨询委员会和RIMI计划主任提供报告。随着拟议的精心策划的RIMI计划，在五年的项目期内，我们预计将增加一倍的研究生产力，这可以在出版物的数量，资助的建议，进入研究生院的学生人数和教师参与生物医学研究的总数。

DESCRIPTION (provided by applicant): The aims of the NCMHD-RIMI program are to reduce health disparities by providing resources to institutions that prepare significant number of minority students and faculty in biomedical sciences. Based on these aims, Virginia State University (VSU) proposes a RIMI program that is aimed to augment and strengthen the infrastructure and capacity of VSU to conduct basic biomedical research which will address and ultimately eliminate health disparities. The program will develop infrastructure to enhance research at VSU, infuse innovative educational experiences to students and faculty, expose faculty and students to cutting-edge biomedical research, and through collaborations enhance minority faculty/student participation in biomedical research. VSU-RIMI program objectives are: I) to build research capacity for biomedical research at VSU, ii) to promote the participation of faculty and students in biomedical and behavioral research, and iii) to enhance academic programs in biomedical sciences and health disparities. VSU-RIMI program proposes four major cores: administrative core, shared resources/infrastructure core, faculty developmental research core, and academic enhancement core. These four cores with the proposed specific aims consist of all major aims which are goals of NCMHD-RIMI program. Within the faculty research core, we propose three research projects which deal with health disparities and human health issues. These subprojects are: 1) Comparative Genomics Strategies for Finding Susceptibility Components for Inherited Human Disease-Diabetes, 2) Study of interaction between presenilin mutations and amyloid protein in development of Alzheimer's disease, and 3) A Comparative and Functional Genomic Approach to Host Susceptibility or Resistance and Immune Responses to Internal Parasite Infections. Our proposed RIMI program will include a team of personnel that will be headed by project director, Dr. Brown, a program coordinator, a research associate and three faculty members serving as co-PIs. Management team will be advised by an institutional advisory committee and overall RIMI program will have an oversight of an external advisory committee. The program includes University of Virginia, Louisiana State University, Utah State University, and College of William and Mary as collaborating institutions which are research intensive institutions. The RIMI program will be evaluated annually by an external consultant and proposed and actual accomplishments will be evaluated and a report will be provided to the external advisory committee and the RIMI program director. With the proposed well-planned RIMI program, within the five year of the project period, we anticipate to double the research productivity which could be measured in the number of publications, funded proposals, number of students entering graduate school and total number of faculty participating in biomedical research.