Behavioral Rx & Nutrition in Pediatric Chronic Disease

描述(由申请人提供)： 本次更新的以患者为中心的研究生涯中期研究员奖的具体目的是：1)促进候选人在行为干预方面的研究，以提高患有囊性纤维化和学龄前肥胖的儿童的饮食依从性和健康结果；2)为候选人提供受保护的时间和资源，指导正在从事儿童行为营养干预临床研究事业的心理学和儿科学初级教员和博士后研究员。这位候选人的计划研究重点是检查影响慢性病儿童饮食依从性的行为因素。在每一种障碍中，目标一直是开发行为干预措施，在严格的临床试验中测试干预措施，并将有效的研究干预措施转化为临床实践。她之前对患有囊性纤维症的学龄儿童所做的工作实现了这些目标，因为它直接导致将行为评估和治疗纳入学龄儿童囊性纤维症的临床护理建议中。这项工作也直接导致了目前的R01，她是其中的联合调查员，将行为干预的应用扩展到患有CF的学龄前儿童。这位候选人在钙的行为饮食干预方面的研究在改善患有幼年类风湿性关节炎和炎症性肠病的儿童的钙摄入量和骨吸收方面同样有效。候选人还拥有初级教师和博士后研究员导师的既定记录，在她上一次获得K24奖项期间，75%的学员获得了NIH的资助。该研究计划包括两个项目：NIH/NIDDK竞争性延续R01临床试验，“帮助儿童肥胖症儿童成长的行为和营养治疗”，以及一项专注于治疗学龄前肥胖的新的干预研究。针对早期职业教师和博士后研究员的指导计划将包括：1)对4名初级教员进行个性化指导，1名是撰写学龄前肥胖领域K23的儿科医生，3名心理学家从K23奖过渡到R奖；2)在当前K24研究项目的背景下，为2名NIDDK T32培训基金的研究员提供以患者为中心的研究强化实践培训，以及开发他们自己的独立研究项目；3)博士后研究员参与有关手稿和拨款撰写、临床试验和临床研究方法学的设计以及临床研究中的伦理的既定教学计划。辛辛那提儿童医院医学中心致力于以患者为中心的研究，拥有强大的儿科综合临床研究中心，并不断推动创新临床研究，包括GCRC的行为核心和儿童行为与营养研究跨学科培训补助金(T32)，这为该奖项的延续提供了理想的环境。

DESCRIPTION (provided by applicant): The Specific Aims of this renewal of a Midcareer Investigator Award in Patient-Oriented Research are 1) to further the candidate's research in behavioral interventions for enhancing dietary adherence and health outcomes in young children with cystic fibrosis and preschool obesity, and 2) to provided the candidate protected time and resources to mentor junior faculty and postdoctoral fellows in psychology and pediatrics who are pursuing clinical research careers in behavioral nutrition interventions for children. The Candidate's programmatic research has focused on examining behavioral factors that affect dietary adherence in children with chronic conditions. In each disorder the aim has been to develop behavioral interventions, test the interventions in rigorous clinical trials, and translate efficacious research interventions into clinical practice. Her previous work with school age children with cystic fibrosis achieved these goals as it directly led to incorporation of behavioral assessment and treatment into recommendations for clinical care of school age children with CF. This work also directly led to a current R01, on which she is a Co Investigator, to extend the application of the behavioral intervention to preschool children with CF. The candidate's research in behavioral dietary interventions for calcium has been equally effective in improving the calcium intake and bone accretion in children with juvenile rheumatoid arthritis and inflammatory bowel disease. The candidate also has an established track record of mentorship of junior faculty and postdoctoral fellows in which 75% of her mentees received NIH funding during the period of her previous K24 award. The Research Plan includes two projects: an NIH/NIDDK competing continuation R01 clinical trial, "Behavioral & Nutrition Treatment to Help CF Preschoolers Grow," and a new intervention study focused on treatment of preschool obesity. The Mentoring Plan for early career faculty and postdoctoral fellows will consist of: 1) individualized mentoring of 4 junior faculty, one will be a pediatrician writing a K23 in the area of preschool obesity and 3 psychologists transitioning from K23s to R awards; 2) intensive practical training in patient-oriented research within the context of the current research projects of the K24 for 2 fellows on the NIDDK T32 training grant, as well as development of their own independent research projects, and 3) participation of postdoctoral fellows in established didactic programs on manuscript and grant writing, design of clinical trials and clinical research methodology, and ethics in clinical research. Cincinnati Children's Hospital Medical Center provides an ideal setting for continuation of this award because of the commitment to patient-oriented research, the presence of a strong pediatric General Clinical Research Center, and ongoing initiatives to promote innovative clinical research including the Behavioral Core of the GCRC and the interdisciplinary training grant in Child Behavior and Nutrition Research (T32).