REFINEMENT OF THE SHIV/MACAQUE MODEL FOR ASSESSMENT OF CANDIDATE MICROBICIDES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景：12只动物经肌内（IM）给予Depo Provera以使阴道粘膜壁变薄。研究方法：治疗后五周，将12只动物分成两组，每组6只动物（安慰剂和活性化合物），并在2 ml凝胶阴道施用后30分钟用高剂量的SHIVSF 162 p3和SHIVSF 33 A混合物攻击。结果/讨论：该实验仍处于确定最终结果的早期阶段。 然而，在双盲研究中，其中凝胶（化合物）被标记，A和B的初步结果是：在A组中：2/6全身感染，在1/4未全身感染的人中检测到病毒斑点，在B组中：5/6全身感染。结果无统计学显著性，P=0.242（Fisher精确检验）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Twelve animals were treated Depo Provera intramuscularly (IM) to thin the wall of the vaginal mucosa. Methods: Five-week post treatment, the 12 animals were divided into two groups of 6 animals each (placebo and active compound) and were challenged with high dose of SHIVSF162p3 and SHIVSF33A mixture 30 minutes post 2ml gel vaginal application. Results/Discussion: This experiment is still in the early stages to determine the final outcome. However, in a double blind study, where the gels (compounds) are labeled, A and B preliminary results are: in Group A: 2/6 systemically infected, with viral blip detected in 1/4 that are not systemically infected and in Group B: 5/6 are systemically infected. The results are not statistically significant, P=0.242 (Fisher exact test).