NIH/NIAID BIODEFENSE PROGRAM

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该TNPRC是通过参与在生物防御和新兴传染病（RCE）在第四和第六区域和区域生物防御实验室（rbl）的建设两个卓越的区域中心参与美国国立卫生研究院/NIAID生物防御和新兴传染病的研究议程。 TNPRC作为两个RCE的非人灵长类核心的一部分。 在非人灵长类动物中的研究对于NIAID A、B和C类因子的治疗和疫苗的开发至关重要。 TNPRC非常适合满足这一关键需求，特别是因为我们在BSL-3的非人灵长类动物中具有传染病研究和模型开发的专业知识。 RBL的具体目标是：1）提供一个基础设施，以支持对A类、B类和C类制剂的区域和国家研究，重点是需要非人灵长类动物的工作; 2）为生物防御研究界提供高度综合的临床护理和实验室调查，以从每种动物身上获得尽可能多的信息; 3）对使用动物的实验进行监督，以确保遵守联邦动物福利和生物安全法规。 TNPRC参与第四和第六区域RCE应用的非人灵长类核心将有助于实现这些目标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The TNPRC is involved in the NIH/NIAID biodefense and emerging infectious diseases research agenda through participation in two of the Regional Centers of Excellence in Biodefense and Emerging Infectious Diseases (RCE) in regions IV and VI and construction of a Regional Biodefense Laboratory (RBL). The TNPRC serves as part of the nonhuman primate core for each the two RCEs. Studies in nonhuman primates will be critical to the development of therapeutics and vaccines for NIAID Category A, B and C agents. The TNPRC is ideally suited to meet this critical need particularly because of our expertise with infectious disease studies and model development in nonhuman primates housed at BSL-3. The specific objectives of the RBL are to: 1) provide an infrastructure to support regional and national research on Category A, B and C agents with a focus on work requiring nonhuman primates; 2) provide highly integrated clinical care and laboratory investigations to the biodefense research community to obtain the maximum amount of information possible from every animal; 3) provide oversight on experiments using animals to assure compliance with federal animal welfare and biosafety regulations. These objectives will be facilitated by the participation of the TNPRC in the nonhuman primate cores of the RCE applications from regions IV and VI.