Infectious Disease Genomics and Bioinformatics Training in Brazil

描述（由申请人提供）：该提案代表了格鲁吉亚大学、里约热内卢Oswaldo Cruz-FIOCRUZ研究所、米纳斯吉拉斯联邦大学和巴西贝洛奥里藏特Rene Rachou研究中心（CPqRR）- FIOCRUZ研究人员之间当前ITGH D43合作培训伙伴关系的更新。CPqRR目前拥有14个实验室和5个NIH资助的研究奖项。该培训提案的目标是在生物信息学，流行病学和分子进化领域建立CPqRR可持续的核心基础设施，以补充现有NIH资助的研究并促进其他实验室进行的研究。CPqRR的研究重点是热带寄生虫，它们的载体和宿主。这些生物包括：疟原虫属，克氏锥虫弓形虫，曼氏血吸虫。按蚊、血脐线虫和人类。该提案旨在通过继续一个非常富有成效的培训计划来满足CPqRR的需求，该计划涉及来自CPqRR 14个实验室中许多实验室的博士前和博士后学生，为期5年。高级培训将通过巴西国内外的讲习班、课程、短期和长期培训进行。培训将涉及源自CPqRR需求的合作研究项目，重点关注血吸虫病的几个方面。这一培训的统一项目将是继续维护和扩展（包括人口多样性和其他“组学”数据）在培训奖第一阶段期间创建和容纳CPqRR的血吸虫基因组数据库。分子进化培训将侧重于血吸虫病媒、血脐蚴，流行病学/生物统计学数据将从现有资助项目中获得并分析。从这次培训和实施活动中获得的技术和知识将直接适用于其他寄生生物的研究。我们将积极寻找合格的候选人进行培训，他们有强烈的愿望返回并为新成立的生物信息学中心的延续贡献他们新获得的专业知识。 公共卫生相关性：对寄生虫病新药和疫苗靶标的需求是巨大的。技术的进步为我们提供了新的数据，涵盖了寄生虫生物学的许多方面。但是，新的数据是复杂的，需要复杂的计算分析和数据库。这项建议旨在培训流行地区的新一代研究人员，利用这些新数据帮助治愈疾病。

DESCRIPTION (provided by applicant): This proposal represents a renewal of a current ITGH D43 collaborative training partnership between researchers at the University of Georgia, the Instituto Oswaldo Cruz-FIOCRUZ in Rio de Janeiro, the Universidade Federal de Minas Gerais and the Centro de Pesquisas Rene Rachou (CPqRR) - FIOCRUZ in Belo Horizonte, Brazil. The CPqRR currently has 14 laboratories and 5 funded NIH research awards. The goal of this training proposal is to establish a sustainable core infrastructure at the CPqRR in the areas of bioinformatics, epidemiology and molecular evolution that will complement existing NIH-funded research and facilitate research conducted in other laboratories. The focus of research at the CPqRR Is tropical parasites, their vectors and their hosts. These organisms include: Plasmodium sp., Trypanosoma cruzi. Toxoplasma gondii, Schistosoma mansoni. Anopheles, Blomphalaria and Humans. This proposal is designed to meet the needs ofthe CPqRR by continuing a very productive training program that involves pre-and post-doctoral students from many of the 14 laboratories at the CPqRR for an additional 5 years. Advanced training will be conducted via workshops, courses, short- and long-term training both within Brazil and abroad. Training will involve collaborative research projects originating from the needs of the CPqRR and focusing on several aspects of schistosomiasis. The unifying project for this training will be the continued maintenance and extension (to include population diversity and other "omics" data) of a Schistosoma genome database created and housed the CPqRR during the first phase of the training award. Molecular evolution training will focus on the Schistosome vector, Blomphalaria and epidemiological/biostatistlcal data will be derived and analyzed from existing funded projects. The technology and knowledge acquired from this training and implementation exercise will be directly applicable to research on other parasitic organisms. We will proactively seek out well qualified candidates for training that have a strong desire to return and contribute their newly acquired expertise to the continuation of a newly founded Center of Bioinformatics. PUBLIC HEALTH RELEVANCE: The need for new drug and vaccine targets for parasitic diseases is tremendous. Advances in technology have provided us with new data that cover many aspects of the biology of the parasites. But, the new data are complex and require sophisticated computational analyses and databases. This proposal is designed to train a new generation of researchers in endemic areas to use this new data to help cure disease.