Center for Regenerative Medicine (CRM) Support for New Faculty Member

描述（由申请人提供）：本申请寻求哈佛医学院马萨诸塞州总医院（MGH）再生医学中心（CRM）新助理教授的支持。这个人将位于最近完成的实验室和CRM办公空间，在MGH主校区，作为Simches大楼内的10个教师物理相邻单元的一部分，其中包括五个跨学科中心。CRM空间是开放的实验室形式，以鼓励互动，包括用于临床级细胞制备的GMP级设施，用于生物工程基质构建的聚合物处理套件和容纳生物信息学专家骨干的计算生物学套件。CRM是一个多学科组织，成立于2003年，由医学、外科、神经外科、细胞生物学、遗传学、干细胞和再生生物学系的个人组成。在对70多名候选人进行审查后，选出了一名在肺部发育和再生生物学以及肺部疾病临床专业知识方面具有出色研究记录的医生兼科学家。Jayaraj Rajagopal博士专注于肺干细胞和再生在人类肺部疾病中的应用。 目的：1.）招募一名专注于以干细胞为基础的人类疾病治疗方法的医生科学家 2.）的情况。建立一个拥有最先进设备的实验室，以提高我们对肺部发育生物学的理解和肺部疾病的潜在应用。促进未来肺部疾病再生医学思想领袖的成功。 与血液和心脏干细胞生物学的最新进展相反，肺部的工作仍然不发达。我们希望招聘一名新的教师候选人到马萨诸塞州总医院的再生医学中心。我们相信我们的候选人对肺干细胞和发育生物学的治疗用途的兴趣将为肺再生医学奠定基础。

DESCRIPTION (provided by applicant): This application is seeking support for a new Assistant Professor in the Center for Regenerative Medicine (CRM), at the Massachusetts General Hospital (MGH), Harvard Medical School. This individual will be located in recently completed laboratory and office space for CRM, on the MGH main campus, as part of a 10 faculty physically adjoined unit within the Simches Building housing five interdisciplinary centers. The CRM space is open lab format to encourage interaction and includes GMP level facilities for clinical grade cell preparations, a polymer handling suite for bioengineered matrix construction and a computational biology suite housing a cadre of bioinformatics experts. The CRM is a multidisciplinary organization established in 2003 incorporating individuals from the Departments of Medicine, Surgery, Neurosurgery, Cell Biology, Genetics and Stem Cell and Regenerative Biology. After review of over 70 candidates, a physician-scientist with a record of excellent research in lung developmental and regenerative biology as well as clinical expertise in lung disease was selected. This candidate, Dr. Jayaraj Rajagopal, is focused on the application of lung stem cells and regeneration to human lung disease. Aims: 1.) To recruit a physician-scientist focusing on stem cell based approaches to human disease 2.) To establish a laboratory with state-of-the-art facilities to enhance our understanding and potential application of lung developmental biology to lung disease.3.) To foster the success of a future thought leader in regenerative medicine for lung disease. In contrast to recent progress in blood and cardiac stem cell biology, work in the lung remains underdeveloped. We wish to recruit a new faculty candidate to the Center for Regenerative Medicine at the Massachusetts General Hospital. We believe our candidate's interest in the therapeutic uses of lung stem cells and developmental biology will lay a foundation for regenerative medicine in the lung.