Yale Cellular Neuroscience, Neurodegeneration and Repair (CNNR) Program

描述（由申请人提供）：耶鲁大学细胞神经科学、神经变性和修复项目（CNNR）由PI和Co-PI四年前共同创立，目标是将神经元细胞生物学的基础研究与推进神经变性疾病和神经修复的病理生理学理解联系起来。我们假设，强大的协同作用将导致在疾病为导向的科学与神经系统的细胞生物学专家的研究人员聚集在一起。到目前为止，我们已经招募了5名新教师进入连续的实验室空间，将他们与耶鲁大学的其他神经科学家联系起来，并建立了一个先进的神经元成像和功能基因组学核心设施。在这里，我们建议招聘两名助理教授进入耶鲁CNNR，以填补我们的计划中未满足的关键需求。现有教师已经启动的有力的研究项目将与两名新成员的研究项目相互交织，并将促进他们的成功和CNNR的整体成功。预计一名新兵将通过提供单细胞水平的电生理专业知识以及光学技术来填补关键角色。使用这些方法的新兵将有一个肥沃的土壤，从现有的CNNR教师中选择分子生物学合作者。这样的招募也将提供一个新的层面正在进行的探索神经元功能的健康和疾病。第二个新兵预计将领导一个以阿尔茨海默病细胞生物学为中心的项目。虽然这是最普遍的神经系统疾病，但耶鲁大学没有主要专注于这种疾病的实验室。有了这个新兵，耶鲁CNNR将允许耶鲁大学的神经细胞生物学财富应用于阿尔茨海默病。重要的是，CNNR环境将为新的助理教授提供强大的基础科学专业知识和新的想法，以改善对这种疾病的病理生理学理解，并最终治疗。耶鲁大学已承诺提供实验室空间，并将为新招聘人员提供三分之二的资金，但拟议的支持对于为耶鲁大学CNNR招聘两名新助理教授提供必要的资源至关重要。

DESCRIPTION (provided by applicant): The Yale Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR) was co-founded by the PI and Co-PI four years ago with the goal of linking basic research in neuronal cell biology with efforts to advance pathophysiological understanding of neurodegenerative disease and neural repair. We hypothesized that strong synergies will result from bringing together researchers in disease-oriented science with experts in the cell biology of the nervous system. To date we have recruited 5 new faculty into contiguous laboratory space, interconnected them with other neuroscientists at Yale, and established an advanced core facility for imaging and functional genomics of neurons. Here, we propose the recruitment of two additional Assistant Professors into the Yale CNNR in order to fill key unmet needs in our Program. The vigorous research programs already launched by existing faculty will interdigitate with those of the two new Recruits and will foster their success and the overall success of the CNNR. It is anticipated that one Recruit will fill a crucial role by providing electrophysiological expertise at the single cell level coupled with optical techniques. A Recruit using these methods will have a fertile ground for selecting molecular biology collaborators from amongst the existing CNNR faculty. Such a Recruit will also provide a new dimension of ongoing explorations of neuronal function in health and disease. The second Recruit is expected to lead a program centered on the cell biology of Alzheimer's Disease. While this is the most prevalent neurological condition, Yale has no laboratory focused primarily on this disorder. With this Recruit, the Yale CNNR will allow the wealth of nerve cell biology at Yale to be applied to Alzheimer's Disease. Importantly, the CNNR environment will provide the new Assistant Professor with a strong basic science expertise and fresh ideas towards an improved pathophysiological understanding, and eventually a treatment, of this condition. Yale has committed laboratory space and will provide two-thirds of the funds for the new Recruits, but the proposed support is essential to provide the resources necessary for recruitment of two new Assistant Professors into the Yale CNNR.