Model human digestive system for the determination of bioaccessibility of environmental pollutants.

该项目将使用一个强大的实验室胃肠道模型来确定人体肠道中环境污染物的生物可吸收性（污染物在肠道内被吸收并与人体细胞相互作用的能力）。这将大大提高监管机构为确定污染物的毒理学及其在人体摄入后的影响而进行的风险评估过程的准确性。当可以准确地确定这一参数时，环境署在监管指南中提供的土壤指导值（SGV）和污染土地评估将得到显着提高。目前，不存在这种可重复的确定方案，并且指导值基于摄入，即个体暴露于而不是摄取的物质的量，进入身体并被血流吸收的污染物的量。该提案汇集了两个已建立的肠道模型。反映胃和小肠行为的BGS模型和模拟结肠的阅读大学模型。上消化道的酸性条件被认为是金属从土壤基质中释放的主要场所，而结肠的丰富微生物作用可能对有机污染物有更大的影响。这两种污染物类别都将在提案中进行测试。两种模型的统一将带来反映整个人类消化道的能力。该提案得到了健康保护局的支持，他们在推导SGV时为环境局提供毒理学支持。HPA将对整个项目期间进行的毒理学分析提供支持和建议。

This project will use a robust laboratory based model of the gastrointestinal tract to determine the bioacessibility (ability of a pollutant to be absorbed within the gut and interact with human cells) of environmental pollutants in the human gut. This will provide a major advance in accuracy of the risk assessment process undertaken by regulatory authorities to determine the toxicology of pollutants and their effects when ingested by humans. When accurate determinations of this parameter can be made, the soil guideline values (SGVs) provided by the Environment Agency in the regulatory guidance and for the assessment of contaminated land, will be significantly enhanced. Currently, no such repeatable determination protocol exists and guidance values are based upon intake, i.e. the amount of substance to which an individual is exposed rather than uptake, the amount of contaminant which enters the body and is taken up by the bloodstream. This proposal brings together two established gut models. The BGS model which mirrors behaviour in the stomach and small intestine and the University of Reading model which simulates the colon. The acidic conditions of the upper gut are believed to be the primary site of release of metals from the soil matrix, whereas the profuse microbial action of the colon may have more of an effect on organic pollutants. Both pollutant classes will be tested in the proposal. Unification of the two models will bring about the ability to mirror the whole human digestive tract. The proposal is supported by the Health Protection Agency who provide toxicological support to the Environment Agency when deriving SGVs. The HPA will support and advise on toxicological analyses conducted throughout this project.