P30 Center in Craniofacial Bone Biology

描述（由申请人提供）：这是一份P30申请，申请在纽约大学牙科学院（NYUCD）建立颅面骨生物学中心。Nicola C. Partridge博士刚刚被聘为纽约大学基础科学和颅面生物学的新主席，其议程是巩固和扩大纽约大学的骨生物学。她是国际知名的骨生物学家。牙科学院现有的许多教职员工都非常关注骨和软骨生长、生物矿化和生物材料。Partridge博士在骨生物学的许多领域拥有丰富的经验和地位，如成骨细胞分化，基质金属蛋白酶，甲状旁腺激素作用，转录，成骨细胞的电磁刺激，趋化因子和破骨细胞，以及管理和指导技能，这将把团队团结在一起，形成一个有凝聚力的实体。除了现有的教员外，帕特里奇博士还将招聘两名新的初级骨生物学基础科学教员。他们将在破骨细胞生物学、骨细胞及其与骨基质的相互作用方面被招募，以补充帕特里奇博士和现有教员的研究领域。新的初级教员将至少有75%的时间用于研究。P30赠款的资金将用于支持这项工作两年，并为他们的启动计划提供部分支持。牙科学院将在奖励期间提供剩余的工资和启动资金，并在P30终止后至少两年继续为教师提供总工资支持和剩余的启动包。帕特里奇博士和两名初级教员的招聘将使纽约大学建立一个强大的跨学科颅面骨生物学中心。

DESCRIPTION (provided by applicant): This is a P30 application to establish a Center in Craniofacial Bone Biology at New York University College of Dentistry (NYUCD). The PI, Dr. Nicola C. Partridge, has just been recruited as the new Chair of Basic Science and Craniofacial Biology at NYUCD with the agenda of consolidating and expanding Bone Biology at NYUCD. She is an internationally renowned, established bone biologist. A number of existing faculty members at the College of Dentistry have a significant focus on bone and cartilage growth, biomineralization and biomaterials. Dr. Partridge brings tremendous experience and stature in a number of areas of bone biology such as osteoblast differentiation, matrix metalloproteinases, parathyroid hormone action, transcription, electromagnetic stimulation of osteoblasts, chemokines and osteoclasts, as well as administrative and mentoring skills, which will pull the group together into a cohesive entity. Together with the existing faculty, Dr. Partridge will recruit two new junior basic science faculty in bone biology. They will be recruited in osteoclast biology, and osteocytes and their interaction with bone matrix to complement Dr. Partridge's and the existing faculty members' areas of research. The new junior faculty will have at least 75% of their time dedicated to research. The funds of the P30 grant will be used to support this effort for two years and provide partial support for their start-up packages. The College of Dentistry will provide the remainder of their salaries and start-up funds during the period of the award and continue to support the faculty with total salary support and the remainder of their start-up packages for at least two additional years after the termination of the P30. The recruitment of Dr. Partridge and two junior faculty will permit the establishment of a strong interdisciplinary Craniofacial Bone Biology Center at NYUCD. PUBLIC HEALTH RELEVANCE: This is a P30 application to establish a Center in Craniofacial Bone Biology at New York University College of Dentistry (NYUCD). This will advance research into understanding important disease processes such as cleft palate and lead to strategies for the repair of such problems along with Craniofacial injuries caused by cancer, accident and war using regenerative medicine techniques.