Relationships Among Interpersonal Stress, Affect Regulation, and Alcohol Lapse

以下对原始申请摘要的修改版本对拟议的研究进行了简洁的描述CI：L：‘， 这项应用的长期目标是利用AUD复发预防干预的有效性，对人际压力、情感调节、情绪迟缓、81岁以下的酒精使用和治疗之间的关系有了不同的理解。这个qpplicatipnha？两个主要目的是：(1)考察激励性三倍努力(定义为一种涉及控制、管理、命令他人的个人关注)、情绪调节及其相互作用之间的关系，以及它们之间的相互作用，分别与第一时间失效和总体酒精使用有关；(2)研究人际事件在激励性争取、情绪调节和第二个月和第三个月饮酒之间作为关系中介的作用。该应用还有两个探索性目的，分别涉及心脏迷走神经紧张性(迷走神经紧张性被认为反映保持HO的能力)作为情感调节的“可能指标”，以及激动性兴奋、情感、调节和感觉到的失落沉淀物含量之间的关系。在这项研究中，156名接受AUD H1患者治疗的男性和女性将在治疗开始时就他们的酒精使用和相关功能、社交能力访谈和愤怒超越挑战进行评估。社交能力面试和愤怒超越挑战WIU提供。自我报告、行为和生理数据是情绪反应的中间压力源，它们分别是激励性努力和情绪调节措施的来源。该-。评估方案将包括通过收集生态瞬时评估数据来测量自然环境中人际事件的感知压力。它将通过使用交互式语音响应技术来获得；eCQ逻辑。。暂时性评估为期4周，治疗期间出院。参赛者将会。在12周的治疗出院后，每两周重新评估他们的酒精使用、酒精吸收和相关信息。与酒精使用和功能相关的其他变量将在6周和12周重新评估。。。。 在这项研究的拟议两年版本中，具体目标不会改变。实际上，我们建议在样本量减少约28%(Newn=156)的情况下实现相同的目标~鉴于这项研究的研究设计，时差不会带来什么困难；·这只是一个比我们最初计划的更早结束患者招募的问题。另一方面，我们会的。NOF必须将招聘人数减少一半(两年的资金支持，而不是四年)，因为我们会做到的。能够通过额外的研究来加速参与者的招募速度来实现。样本量为72%，原建议的N=216。请注意，ARRA基金第一年和第二年的拟议预算反映了比最初为四年协议提议的更多的员工招聘，从而可以加快招募速度。我们预计有足够的患者流Cit。临床参与招聘地点UU将实现这种加速的招募速度。我们估计，修订的样本大小将允许足够的能力来检测感兴趣的中等效应大小。在这方面，原始应用程序的项目样本大小要求保守地基于中小效应大小估计，并且即使在那样的计算下，对于测试的一些效应，功率也等于1.00；我们预计实际的临界效应大小接近中等大小。

The following modified versionofthe original application's Abstract gives a succinct description of the proposed researCI:l: ' , This application'slong-ferl11' goal is toenharice the effectiveness of AUD relapse prevention interventions lhroughadVaricing understanding of the relationships among interpersonal stress, affect regulation, alc()hollapse, 81ld pat~erns of alcohol ' usefoHowing AUD treatment. This qpplicatipnha? two major aims: (1) To investigate the association ofAgonistic$triving (defined as a 'preoccupationwithpersonalgpalsthat involve controlling, managing, ordomiqating other ' people), affect regulation, and their interaction, with time to first lapse,and overallalcohpl use, " respectively, and (2)To investi!:jate the role of interpersonal events as mediatprs of the relationship , among Agonistic Striving, affect regulation, andi3lcohol consumption in the second and third monthspost-treatrnent. The application also has 2 exploratory aims that concern the investigation of cardiac vagal tone (Vagal tone 'isthought to reflecttheabiiitytoniaintain hOJl1eQstasis)as a ' possipleindicator of affect regulation,and the relationship among Agonistic Strivi'lg, affect , regulation, and the content of perceived lapse preCipitants, fflspectively. In this study, 156 men and women,admitted to AUD h1patient treatment will be assessed at treatment entry on their alcohol ' use and related functioning, the Social Cqmpetence Interview, and Anger Transcendence Challenge. The Social Competence Interview and Anger Transcendence Challenge wiU provide . self-report, behavi()ral, and physiological data on affective responses tointerpersbr18lstressors and are the sources:of measures of Agonistic Striving and affect regulatibn,respectively. The - . assessment protocol \3lso Will include measurement of the perceivedstressfulness of interpersonal events in thenaturalenvironmentthrough the collection 6fecological momentary assessment data, . Which will be obtained by use of Interactive Voice Response technology; The eCQlogical . . momentary~ assessment will occur for 4 weeksfcillowing treatment discharge. participants will. be re'-assesseq oil their alcohol use, alcohoUapses, and relClted information biweekly following · treatment discharge over the course of12weeks. Additionalvariables related to alco~oluse ahd relat~d functioning wHl be reassessed at6 and 12 weeks. . . . In the proposed two-ye.ar version ofthis study; the specific aims will· not change. In effect, we propose toaccomplish~he same aims with a sample size reduced by about 28 percent (newN= 156)~Given the research design of this study, the time difference will pose little difficulty;· it simply will be a matter ofending patient recruitment earlier than we had planned origirially.On the other hand, we Will. nof have to reduce recruitment by half (2 years of fundingasopposed to 4), because We will be. able to hi.re additional research st~ff to accelerate participant recruitment rate to achieve . a sample-size thafis72percentoJ the originally proposed N= 216. Note that the proposed budget forYear 1 and Year 2 ofARRA funds reflects the hiring 'ofmorestaffthan originally proposed for the4-yearprotocolsothat recrui.tment can be accelerated. We expectsuffident patient flow Citthe . clinical site of participalitrecruitmenUo achieve this accelerated recruitment rate. We estimate that the revised sample size will allow sufficient power to detect medium effect sizes _ of interest. In this regard, the original application's proJectedsample size requirementswere conservatively based on small-medium effect size estimates, and calculations, even at that, showed power equal to 1.00 for · 'Some of the effects tested; We expect actual critical effect Sizes closer to medium magnitude.