Administrative Core

华盛顿大学睡眠障碍管理研究中心的使命 (UW-CRMSD)是通过提高睡眠质量来改善健康、福祉和生活质量 在整个生命周期内。睡眠障碍是常见的、严重的、代价高昂的，而且是可以治疗的。中国有7000多万人 美国人有某种类型的睡眠障碍，许多人没有意识到他们有问题。沉睡 睡眠障碍与特定的睡眠障碍有关(如失眠、睡眠呼吸紊乱、不安宁 腿综合征)，通常与急性和慢性疾病状态(例如，关节炎，神经疾病， 抑郁)或在发育过渡期间(如青春期、更年期、退休)出现，并且是 有时由于生活方式的选择，如工作或照顾的需要，而自我强加。不管病因是什么， 睡眠障碍最常见的表现为睡眠中断或支离破碎，或睡眠不足。 未经治疗的睡眠障碍会造成严重的白天后果，并使所有年龄段的人处于 造成不良健康后果的风险相当大。儿童和老年人特别容易受到不良影响 未被识别和治疗的睡眠障碍造成的健康后果。图1总结了一个概念性 睡眠障碍与健康结局之间关系的框架，可发生在睡眠障碍的任何阶段 人类的寿命。UW-CRMSD将解决多因素(例如，遗传、环境、 年龄/发育)睡眠障碍的性质以及支持制定干预措施以改善 睡眠质量考虑了重要的影响因素，如年龄、发育转变和 慢性病(图1)1. 总体中锋目标。 1)开发和维护支持以下内容的基础设施 并支持翻译研究以改善睡眠 整个生命周期的质量；2)提供管理、 为项目和项目提供财务、技术和学术支持 初步研究；3)加强和保持强大 研究人员之间的跨学科伙伴关系 促进将研究成果转化为 实践；4)完善现有协议并开发新协议 提供可靠、精确且经济实惠的最新技术 支持新的和正在进行的方法所需的方法 适用于发育和年龄适中的自我报告 (患者报告的结果测量信息系统[PROIS]测量)，行为 (肌动描记)和生理睡眠(PSG)测量；5)创建用于试验和未来遗传标记的存储库 研究；6)增加对进行与睡眠障碍有关的研究感兴趣的研究人员的多样性 此应用程序的关键组件包括： ？关注慢性病患者一生中的睡眠障碍。对发育和年龄敏感 工具将用于儿童(Ward)、成人(Watson)和老年人(taibi，Thompson)。 ？2个核心，将为四个项目和试点赠款提供基础设施支助。 ？4个利用电子数据收集、Promis测量和生物行为标记的研究项目 项目、试点和附属调查人员的质量指导 ？UW通过提供资金支持试点/小额赠款计划，支持中心的可持续性 对管理睡眠障碍的转化性研究的可持续性至关重要。 ？CRMSD建立在妇女健康和性别研究中心(NINR资助的1989-2009年)和 翻译健康科学研究所创建了最初的基础设施、社区推广、 以及大学氛围，为这一新的、专注于症状研究的领域奠定了基础。

The mission of the University of Washington Center for Research on Management of Sleep Disturbances (UW-CRMSD) is to improve health, well being, and quality of life through the enhancement of sleep quality across the lifespan. Sleep disturbances are common, serious, costly and treatable. Over 70 million people In the U.S. have some type of sleep disturbance and many are unaware that they have a problem.'' Sleep disturbances are associated with particular sleep disorders (e.g. insomnia, sleep disordered breathing, restless legs syndrome), are often co-morbid with acute and chronic illness states (e.g. arthritis, neurologic disorders, depression) or arise during developmental transitions (e.g. adolescence, menopause, retirement), and are sometimes self-imposed due to lifestyle choices, such as work or caregiving demands. Regardless of etiology, sleep disturbances most often manifest as disrupted or fragmented sleep or as an inadequate amount of sleep. Untreated sleep disturbances pose significant daytime consequences and place individuals of all ages at considerable risk for adverse health outcomes. Children and the elderly are particularly vulnerable to adverse health outcomes from unrecognized and untreated sleep disturbances. Fig, 1 summarizes a conceptual framework for the relationship between sleep disturbances and health outcomes that can occur at any stage of the human lifespan. The UW-CRMSD will address the multi-factorial (e.g., genetics, environment, age/development) nature of sleep disturbances as well as support the development of interventions to improve sleep quality that take Into account important contributing factors such as age, developmental transitions, and chronic illness (Fig. 1).1 Overall Center Goals. 1) Develop and maintain an infrastructure that supports and sustains translational research to improve sleep quality across the lifespan; 2) Provide administrative, financial, technical, & scholarly support to Project & Pilot studies; 3) Enhance & maintain strong interdisciplinary partnerships among researchers to promote the translation of research findings into practice; 4) Refine existing and develop new protocols for 'state of the art' reliable, precise, and cost-effective methods needed to support new and ongoing methods for developmentally and age-appropriate self-report (Patient-Reported Outcomes Measurement Information System [PROMIS] measures), behavioral (actigraphy), and physiologic sleep (PSG) measures; 5) Create a repository for pilot and future genetic marker studies; 6) Increase the diversity of investigators interested in pursuing research related to sleep disturbances Key components of this application include: ¿ Focus on sleep disturbances across the lifespan in persons with chronic illness. Developmentally and agesensitive tools will be used with children (Ward), adults (Watson), and older adults (Taibi, Thompson). ¿ 2 Cores which will provide infrastructure support for the four Projects and Pilot grants. ¿ 4 research Projects that utilize electronic data collection, PROMIS measures, and biobehavioral markers ¿ Quality mentorship ofthe Project, Pilot, and Affiliate Investigators ¿ UW support for Center sustainability through provision of funds supporting a pilot/small grants program critical to the sustainability of translational research to manage sleep disturbances. ¿ The CRMSD builds on the Center for Women's Health & Gender Research (NINR funded 1989-2009) & the Institute for Translational Health Sciences (ITHS) which created the initial infrastructure, community outreach, and collegial atmosphere that set the stage for this new, focused area of symptom research.