Center for Research on the Management of Sleep Disturbances

描述（由申请人提供）：睡眠障碍是一种常见、严重、昂贵且可治疗的疾病。在美国，有超过7000万人患有某种类型的睡眠障碍，许多人并没有意识到自己有这个问题。睡眠障碍与特定的睡眠障碍有关，通常与急性和慢性疾病并存，或在发育过渡期间出现，有时是由于生活方式的选择而自我强加的。华盛顿大学睡眠障碍管理研究中心（UW-CRMSD）将通过提高整个生命周期的睡眠质量来改善健康、幸福和生活质量。UW-CRMSD将解决睡眠障碍的多因素性质，并收集对个性化干预措施发展重要的初步数据，以改善睡眠质量。该应用程序的主要组成部分包括：基于CRMSD主题的四个中心项目-睡眠障碍，慢性疾病和自我管理；注意对年龄和发展敏感的措施；机构支持的试点项目方案；中心研究人员与转化健康科学研究所的整合；还有很强的评估成分。所有中心和试点项目将共同使用生物行为工具核心进行电子数据收集、PROMIS测量和生物行为标记（活动记录），以确保数据质量和可比性。中心和试点项目产生的数据将用于数据共享。UW-CRMSD将由一个多学科的执行委员会和行政核心领导，并由由睡眠和自我管理研究领域的国家领导人组成的内部和外部科学咨询委员会提供支持。行政核心的主要职责将包括：对中心所有活动进行科学和财政监督；监督和评估所有中心和试点项目，研究者指导；辅助调查员的发展；提供中心范围内的教育机会；向少数民族人口伸出援手，促进中心的可持续性；以及将研究成果翻译和传播给临床合作伙伴。

DESCRIPTION (provided by applicant): Sleep disturbances are common, serious, costly and treatable. Over 70 million people in the US have some type of sleep disturbance and many are unaware that they have a problem. Sleep disturbances are associated with particular sleep disorders, are often co-morbid with acute and chronic illness states or arise during developmental transitions, and are sometimes self-imposed due to lifestyle choices. The University of Washington Center for Research on Management of Sleep Disturbances (UW-CRMSD) will improve health, well being, and quality of life through the enhancement of sleep quality across the lifespan. The UW-CRMSD will address the multi-factorial nature of sleep disturbances as well as gather preliminary data important to the development of personalized interventions to improve sleep quality. Key components of this application include: four Center projects based on the themes of the CRMSD - sleep disturbances, chronic illness, and self management; attention given to age and developmentally sensitive measures; an institutionally supported pilot projects program; integration of Center investigators with the Institute for Translational Health Sciences; and a strong evaluative component. All Center and pilot projects will make common use of the Biobehavioral Tool Core for electronic data collection, PROMIS measures, and biobehavioral markers (actigraphy) to ensure data quality and comparability. Data generated by Center and pilot projects will be available for data sharing. The UW-CRMSD will be led by a multi-disciplinary Executive Committee and Administrative Core supported by Internal and External Scientific Advisory Committees comprised of national leaders in sleep and self management research. Key responsibilities of the Administrative Core will include: scientific and fiscal oversight of all Center activities; oversight and evaluation of all Center and pilot projects, investigator mentorship; development of adjunct investigators; provision of Center-wide educational opportunities; outreach to minority populations, facilitating Center sustainability; and translation and dissemination of research findings to clinical partners. PUBLIC HEALTH RELEVANCE: More than 70 Million Americans suffer from sleep disturbances which results in reduced health-related quality of life. The University of Washington Center for Research on Management of Sleep Disturbances addresses this significant public health problem by conducting multidisciplinary research across the lifespan. The implications of this research across conditions and life stages will be enhanced by the use of common sleep and symptom measures across projects. CENTER AS A WHOLE, INCLUDING ADMINISTRATIVE CORE AND EVALUATION PLAN