IMMUNOLOGIC ABNORMALITIES, CHRONIC INFLAMMATION AND OXIDATIVE STRESS IN CKD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 越来越清楚的是，慢性肾脏疾病(CKD)晚期患者死亡的常见原因是心血管疾病和感染，与免疫系统异常有关，免疫系统异常是慢性炎症和氧化应激的基本状态。在慢性肾脏病人群中，这些过程没有被仔细描述。我们打算对慢性肾脏病患者的免疫系统进行一项全面的研究，并描述其与慢性炎症和氧化应激的关系。 这项研究的目的是： B7确定CKD患者循环免疫细胞(中性粒细胞、单核细胞、淋巴细胞)的异常 B7确定慢性肾脏病慢性炎症和氧化应激的相关因素和程度 B7确定慢性肾脏病不同阶段和透析治疗对这些异常的贡献 在这项研究中，我们将对不同程度肾功能减退的CKD患者的免疫功能、氧化应激和炎症进行全面的评估，并将这些结果与肾功能正常的患者进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is becoming clear that the common causes of mortality in patients with late stages of chronic kidney disease (CKD), cardiovascular disease and infections, are associated with abnormalities of the immune system, an underlying state of chronic inflammation and oxidative stress. These processes have not been carefully described in the CKD population. We intend to conduct a comprehensive study of the immune system in individuals with CKD and describe the association with chronic inflammation and oxidative stress in that population. The aims of this study are: 'b7 To identify abnormalities of circulating immune cells (neutrophils, monocytes, lymphocytes) in patients with CKD 'b7 Identify factors responsible for and define the extent of chronic inflammation and oxidative stress in CKD 'b7 Determine the contribution of different stages of CKD and of the dialysis treatment on these abnormalities In this study, we will provide a comprehensive evaluation of immune function, oxidative stress and inflammation in CKD patients with varying levels of reduced kidney function and compare these findings to those in individuals with normal kidney function.